Gepabene in the treatment of chronic diffuse liver diseases and biliary dyskinesias. Gepabene for the protection and treatment of the liver How to take "Gepabene" in the treatment of the liver

Which drug should be used to treat liver diseases: "Gepabene" or "Essentiale"? In any case, the choice of a drug should be left to the attending physician, who, having studied the results of a diagnostic examination, determines the appropriateness of using a particular medication. "Gepabene" is a combined remedy of plant origin, the action of which is aimed at normalizing the functioning of the liver in various ailments. You need to take the medication after reading its instructions.

Release form and composition

Gepabene is produced in the form of capsules, which have a light brown color and a hard gelatinous structure. Inside each capsule is a powdery consistency with an orange-brown tint. Tablets are placed in blisters of 10 pieces, in packs there are 3 or 10 blisters. The components of the medication are:

• extract of grass wild rue;
• milk thistle extract;
• magnesium salt of stearic acid;
• ethylene glycol polymer;
• corn starch;
• gelatin;
• food additive E172;
• distilled water;
• food additive E171.

Mechanism of action

The pharmaceutical preparation, due to its combined composition, has the ability to stop the convulsive contraction of the gallbladder and its ducts, thereby allowing bile to enter the intestine more easily. Entering the body, the constituent drugs normalize the amount of secretion. The active formula exhibits an antitoxic effect, which is important in cases of intoxication. The main advantage of "Gepabene" is its ability to form new liver cells and cope with various kinds of pathological processes in this organ. The medicine, entering the digestive organ, mixes with bile and begins to break down in the intestines and liver.

Indications

Plant extracts in the composition of the drug have a hepatoprotective effect in acute and chronic intoxications.

It is recommended to use "Gepabene" as part of the complex treatment and prevention of various ailments of the biliary tract and liver diseases. The components in the composition of the described medication allow you to treat such pathological conditions in the human body:

• impaired motility of the biliary tract;
• inflammation of the digestive gland responsible for the production of bile, occurring in the chronic stage;
• liver disease, characterized by the death of liver tissue;
• fatty liver.

How to take "Gepabene" in the treatment of the liver?

It is necessary to use the pharmaceutical agent "Gepabene" strictly according to the instructions and after consulting with a specialized doctor. The medicine is taken orally during meals, 1 capsule three times a day. The pill is swallowed whole, without biting, washed down with a sufficient volume of purified water. When the patient is worried about severe pain, doctors are allowed to drink 1 more capsule at bedtime. The dosage calculated per day should not exceed 6 pills, divided into 3-4 doses per day.

Can it be used during pregnancy and lactation?

It is allowed to use the drug "Gepabene" for women in the position for the liver in extreme cases and only as directed by a specialized doctor. Gepabene is also taken with caution during the lactation period, since the components of the medicine are able to penetrate into breast milk. Dosage for pregnant and lactating women is selected individually.

Contraindications

The drug is not recommended for use in children under 6 years of age, as well as in case of hypersensitivity to the components of the drug. Contraindications are acute forms of liver diseases and diseases of the bile ducts, through which bile is transported. The instructions for Gepabene indicate that for its use in aged patients and children, dose adjustment is not required and the intake occurs according to the general scheme. When using "Gepabene" it is contraindicated to drink alcoholic beverages. In the process of treatment, it is extremely important to follow a therapeutic diet.

Overdose

The drug is taken after consulting a doctor.

To date, no cases of overdose with the described pharmaceutical agent have been identified. However, if it occurs, you should immediately contact a medical institution for qualified medical help. To prevent an overdose, the medicine must be taken strictly according to the scheme prescribed by the attending physician.

Side effects

Usually "Gepabene" is well tolerated by patients and does not show serious side symptoms. It is extremely rare that, due to its diuretic action, the medication provokes frequent loose stools. In the process of using this medicine for the treatment of ailments of the liver or biliary tract, an increased level of urine production, as well as allergic reactions, may be observed.

Drug analogues

If for some reason it is not possible to take "Gepabene", the patient may be prescribed his analog drugs. According to the active substance, the drug has no synonyms, as it is made on the basis of plant components, which provide it with a unique composition. According to the pharmacological group, the analogues of "Gepabene" are:

• "Ursosan";
• "Karsil";
• "Heptral";
• "Vitanorm";
• "Hepatosan";
• "Antraliv";
• "Essliver";
• "Hepa Merz";
• "Silymarin";
• "Thiolipon";
• "Heptor";
• "Legalon";
• "Octolipen";
• "Geptrong";
• "Erbisol";
• "Molixan";
• "Silimar";
• "Glutargin";
• "Cavehol";
• "Tykveol";
• "Ursodez";
• "Octolipen";
• "Hepabos";
• "Maxar";
• "Thiotriazolin";
• "Milif";
• "Ornitsetol";
• "Silegon";
• "Choludexan";
• "Urdoksa";
• "Metrop";
• "Sirepar";
• "Ursofalk";
• Livedox;
• "Choludexan";
• "Essentiale N";
• "Rezalut Pro";
• "Ursor";
• "Methionine";
• "Phosfonciale";
• "Ornitsetil";
• "Lipoid";
• "Essentiale forte N".

The drug improves the functional state of liver cells.

It should be borne in mind that each drug has its own instructions for use, contraindications and features of use. Therefore, they use the analogue of "Gepobene" only after consultation with the attending doctor, who will assess the patient's condition and prescribe the necessary therapeutic regimen. Otherwise, the risk of side symptoms and complications of the course of the disease increases.

Gepabene is a combined herbal medicine used in the treatment of chronic liver damage and biliary dyskinesia.

pharmachologic effect

The action of the drug Gepabene is due to its active substances of plant origin:

• Dymyanka officinalis (in the form of an extract) contains the alkaloid fumarin, which normalizes the amount of secreted bile, reduces the severity of spasms of the gallbladder and bile ducts, facilitates the flow of bile into the intestine;
• The fruits of milk thistle (in the form of an extract) contain silymarin, which has a hepatoprotective effect and membrane stabilizing activity. The plant is effective against the background of acute and chronic intoxications, as it binds free radicals and toxic substances in the liver tissue. Milk thistle also helps to restore hepatocytes and stimulate protein synthesis.

According to reviews, Gepabene is effective, if necessary, to normalize liver function against the background of many acute and chronic pathological conditions.

Composition, form of release and analogues of Gepabene

Gepabene medication is produced in the form of light brown capsules containing:

• 275.1 mg of dry extract of herb fumes officinalis;
• 83.1 mg of dry extract of milk thistle fruits;
• Auxiliary components: microcrystalline cellulose, magnesium stearate, corn starch, talc, copolyvidone, macrogol 6000 and silicon dioxide.

In some cases, it is possible to prescribe Gepabene analogues, which belong to the same pharmacological group and have a similar therapeutic effect:

• Tablets - Allochol, Berberine, Convaflavin, Liobil, Odeston, Flamin, Tsikvalon, Artichoke extract, Hofitol;
• Tincture - Arnica tincture, Barberry leaf tincture;
• Dragee - Artichoke extract;
• Capsules - Olimetin, Holebil;
• Vegetable raw materials - Choleretic collection, Corn columns with stigmas, Tanacehol, Tansy flowers, Rosehip low-vitamin fruits;
• Syrup - Holos, Holosas, Holemaks.

Indications for use of Gepabene

Gepabene according to the instructions is prescribed as part of complex treatment:

• Biliary dyskinesia, including conditions after cholecystectomy;
• Chronic hepatitis and toxic liver damage.

The possibility of using Gepabene by pregnant and lactating women should be discussed with the attending physician, who will be able to assess the ratio of the expected benefit and the expected risk from taking the medication.

Contraindications

Gepabene capsules should not be taken:

• Against the background of hypersensitivity to plant components (extracts of the herb fumes officinalis and fruits of milk thistle) and excipients;
• Children and adolescents under 18 years of age;
• Against the background of acute inflammatory diseases of the liver and biliary tract.

How to use Gepabene

Gepabene according to the instructions is usually taken one capsule three times a day.

Against the background of pain that occurs at night, it is possible to take an additional capsule just before bedtime. The maximum allowable daily dosage is 6 capsules of Gepabene, divided into 3-4 doses.

According to reviews, Gepabene is most effective while observing the regimen prescribed by the doctor (including refusing to take alcoholic beverages for the duration of treatment), diet and other medicinal prescriptions.

Side effects

Gepabene reviews are usually well tolerated. Sometimes against the background of the use of the drug may occur:

• Minor allergic reactions;
• Digestive disorders;
• Increased diuresis.

There are no data on drug overdose. If unusual symptoms occur during the use of the drug, it is recommended to consult a doctor.

Gepabene drug interactions

The drug interaction of Gepabene with other medicines has not been studied, therefore, if the simultaneous use of drugs is necessary, it is necessary to clarify with the doctor the scheme for taking them.

Storage conditions

Gepabene, according to the instructions, refers to herbal medicines that regulate the work of the digestive tract, the release from pharmacies of which is possible without a doctor's prescription. The shelf life of the capsules is 5 years, provided they are stored at a temperature not exceeding 25 degrees Celsius.

Gepabene is a combined herbal hepatoprotector with unique therapeutic properties, making the drug equally effective in both liver diseases (hepatitis, toxic lesions) and biliary tract motility disorders. In the late 60s of the last century, the flavonoid silymarin, which has a pronounced hepatoprotective effect, was obtained from the fruits of milk thistle. It exhibits membrane-stabilizing, antioxidant and metabolic effects. Interacting with the membranes of liver cells, it ensures their stabilization. Suppressing the activity of the enzyme phosphodiesterase, silymarin promotes the accumulation of cyclic AMP in hepatocytes. From a number of other hepatoprotective compounds, silymarin is distinguished by the presence of the ability to inactivate the transport systems of a number of toxins. So, this mechanism of action of this substance is very much in demand in case of poisoning with a pale toadstool. A number of liver-damaging substances are capable of generating large amounts of aggressive free radicals. Silymarin binds free radicals and breaks the cycle of oxidative degradation of lipids. The metabolic effect of silymarin is associated with the activation of protein synthesis and the acceleration of the recovery of damaged liver cells. The main therapeutic tool of the second active ingredient of Gepabene - a dry extract of a medicinal fume - is the fumarin alkaloid, which has antispasmodic, cholelytic and choleretic effects.

Increases appetite, normalizes the process of digestion, has a tonic effect. Gepabene is contraindicated in case of individual intolerance to the components, which practically does not occur, and in the presence of an acute inflammatory process localized in the liver or biliary tract. Pregnancy and lactation are not direct contraindications to taking the drug, but during this period it is necessary to be especially careful and be constantly monitored by a doctor. The optimal time for taking the drug is during meals. Gepabene capsules are not intended for chewing - they can only be swallowed. Multiplicity of reception - 3-4 times a day. The maximum daily dose at a given frequency of administration is 3-4 times a day. During the medication course, patients should adhere to the dietary recommendations received from the doctor and refrain from consuming alcoholic beverages. Gepabene practically does not show any side effects, with the exception of rare cases of allergic reactions. During pharmacotherapy, the frequency of defecation or urination may increase, which has no clinical significance and cannot be a reason for interrupting treatment. Cases of overdose or addiction to Gepabene in medicine have not yet been described.

Pharmacology

Combined preparation of plant origin, contains extract of fumes officinalis and milk thistle extract. The fumarin alkaloid extract normalizes the amount of secreted bile, relieves spasm of the gallbladder and bile ducts, facilitating the flow of bile into the intestines.

Milk thistle fruit extract contains silymarin, which exhibits a hepatoprotective effect in acute and chronic intoxications, binds free radicals and toxic substances in the liver tissue, has antioxidant and membrane stabilizing activity, stimulates protein synthesis, promotes the restoration of liver cells.

Gepabene normalizes liver function in various chronic pathological conditions.

Pharmacokinetics

After oral administration, the flavonoids that make up silymarin are excreted mainly in the bile and undergo enterohepatic recirculation.

Release form

Capsules hard gelatin, size No. 0, light brown; the contents of the capsules are a powder from orange-brown to light brown in color, with lighter inclusions.

Excipients: microcrystalline cellulose - 80.1 mg, corn starch - 20.1 mg, talc - 8.4 mg, macrogol 6000 - 4.5 mg, copolividone - 4.5 mg, magnesium stearate - 2.1 mg, silicon dioxide - 2.1 mg.

The composition of the capsule shell: gelatin - 79.94 mg, yellow iron oxide - 0.67 mg, red iron oxide - 0.15 mg, black iron oxide - 0.04 mg, titanium dioxide - 1.29 mg, purified water - 13.92 mg.

10 pieces. - blisters (3) - packs of cardboard.

Dosage

The drug should be taken orally during meals, without chewing, with a small amount of water.

For adults, the drug is prescribed 1 capsule 3 times / day.

If necessary, the daily dose of the drug can be increased to 6 capsules (maximum daily dose) in 3-4 doses during the day.

Overdose

So far, overdose phenomena have not been described.

In cases of overdose, the patient should immediately consult a doctor.

Interaction

So far not described.

Side effects

Possibly: allergic reactions.

Sometimes: laxative effect, increased diuresis.

Indications

• as part of the complex therapy of biliary dyskinesia (including after cholecystectomy);
• as part of complex therapy for chronic hepatitis;
• as part of complex therapy for chronic toxic liver damage.

The active ingredients of the drug are extracts from plants. These components have a positive effect on the functioning of the liver and gallbladder. Dymyanka officinalis extract has a choleretic effect, normalizes the amount and composition of bile formed. It restores the tone of the bile ducts, which improves the outflow of secretions.

Indications

Gepabene capsules are used for the treatment and prevention of diseases of the bile ducts. Including the tool is shown with a decrease in motility of the biliary tract, as well as after removal of the gallbladder. In addition, "Gepabene" is recommended for chronic inflammatory liver diseases - as well as for regular toxic lesions of this organ.

Instructions for use

The drug "Gepabene" should be taken 1 tablet 3 times a day. If the pain bothers at night, the dosage can be supplemented with 1 more, which must be drunk before bedtime. The maximum daily dose is 6 Gepabene capsules. This amount of funds should be taken 3-4 times a day.

The medicine should be taken with meals. Capsules should be swallowed whole with water. During the treatment period, you should follow the diet prescribed by your doctor. Also during therapy it is forbidden to drink alcohol and preparations containing ethanol.

Cautions

The drug "Gepabene" should not be used in acute inflammatory diseases of the bile ducts and liver. This remedy is contraindicated in children under 18 years of age, as well as persons allergic to the constituent drugs. Lactating and pregnant women can take "Gepabene" only as directed by a doctor.

Treatment with Gepabene usually proceeds well. In rare cases, the drug can cause side effects in the form of an allergic rash, increased urination. Also, when taking this medication, a slight laxative effect is possible, which occurs due to a decrease in the tone of the bile ducts and the active excretion of bile secretion into the intestine.

Content

The liver is a vital gland involved in the regulation of many processes in the body, neutralizing toxins and other harmful substances. Often pathological processes or liver overload affect it in a destructive way, which necessitates the use of maintenance drugs. One of the most effective drugs is Gepabene - a remedy based on powerful natural ingredients that restore liver cells.

Instructions for use Gepabene

Gepabene is a hepatoprotector of natural origin. The active substances of the drug restore the structure of the liver cells, normalizing the metabolic process. In order to avoid mistakes when taking the drug, it is necessary to read the instructions for use, which describes in detail the indications, the mode of administration, contraindications and other useful data.

Composition and form of release

The drug is available in the form of capsules, which are packed in blisters of 10 pieces. Three blisters are packed in one carton box. Capsules are light brown, hard, gelatinous. The capsules contain a powder of light brown or orange-brown color with light patches. The composition of the drug is presented in the table:

	Weight, mg
Dry extract of the medicinal herb Dymyanka (active ingredient) - corresponds to 4.13 mg of fumaric alkaloids in terms of protopin.
Dry extract of milk thistle fruits - corresponds to 50 mg of silymarin (not less than 22 mg of silybin).
Auxiliary components:
corn starch
copovidone
macrogol 6000
microcrystalline cellulose
magnesium stearate
silicon dioxide colloidal
Capsule composition:
iron oxide yellow
iron oxide red
iron oxide black
titanium dioxide
purified water

Pharmacodynamics and pharmacokinetics

Gepabene's instruction says that the drug belongs to hepatoprotective and choleretic drugs. This is a herbal combination remedy based on extracts of pharmacy fumes and spotted milk thistle. Due to them, the effects of the drug are manifested, which are used by medicine to normalize liver function in the event of its pathological malfunctions.

Pharmaceutical smoke contains the alkaloid fumarin, which normalizes the volume of secreted bile, facilitates its flow to the intestines, which helps to relieve spasms of the gallbladder and its ducts. Spotted milk thistle contains silymarin, which has a pronounced hepatoprotective property, eliminates chronic and acute liver intoxications. It acts by binding in the tissues of the liver of toxins and free radicals.

Silymarin stimulates protein synthesis, acts as a membrane stabilizer and antioxidant, accelerates the process of recovery of damaged liver cells - hepatocytes. Oral intake of capsules promotes the passage of flavonoids and silymarin through the intestines and liver. Metabolites of the drug are excreted (excreted) from the body with bile.

Indications for use

Gepabene capsules are indicated for the treatment and restoration of liver tissue that has undergone stress due to the following conditions:

• chronic hepatitis;
• hepatic lesions of a toxic nature;
• dysfunction of the biliary tract, including conditions associated with cholecystectomy (removal of the gallbladder) as part of complex therapy;
• fatty liver syndrome.

How to take Gepabene

The drug is taken with meals, one capsule with water. The standard dosage of the drug is one capsule three times a day. For pain in the liver at night, an additional capsule is prescribed (in the evening). The maximum allowable dose is two capsules three times a day. At the same time, the consequences of an overdose have not been studied to date.

special instructions

The therapeutic course of treatment with Gepabene should take place against the background of strict adherence to the diet and regimen corresponding to the underlying disease, approved by the attending physician. We allow the simultaneous use of only those drugs that are agreed with the doctor. During the period of taking the medicine, you should refrain from drinking alcohol.

Gepabene during pregnancy

Special purposeful studies of the effect of the drug Gepabene on the body during pregnancy have not been conducted. Also, the possible risks to the fetus have not been studied. At the same time, the drug did not have dangerous side effects. Therefore, the appointment and administration of the medication is at the discretion of the therapist. An independent decision can be made only in case of emergency.

For children

The child's body is in the process of constant change and development, therefore the effects of the influence of active substances stimulating the liver of Gepabene are not amenable to objective study. Experts agree that under the age of 18, course therapy with the drug should be prohibited. This restriction is prescribed in the instructions for use of the product.

drug interaction

Gepabene tablets can be combined with any other drugs, with the exception of other hepatoprotectors. The instructions for use do not describe the action of the drug with other drugs, but with combined treatment for one or another combination, you need to get the doctor's permission. During the entire period of drug therapy, it is forbidden to take alcohol.

side effects

The drug Gepabene is well tolerated by most patients, it exhibits minimal side effects. Of the most famous, which are noted when taking capsules, allergic reactions are distinguished (skin rash, itching, irritation, urticaria, anaphylactic shock, angioedema), loosening of the stool, an increase in the amount of urine excreted (diuresis), its recirculation.

Overdose

To date, not a single case of overdose with capsules of the drug has been described. The safety of the drug is associated with its plant base, which is excreted from the body without causing harm. If an excess of the dose brings negative reactions (nausea, vomiting, dizziness, weakness), the patient needs to visit a doctor, seek medical help.

Contraindications

Herbal components of the drug impose restrictions on its use in a number of patients. Contraindications for taking capsules are:

• hypersensitivity of the body to the components of the composition, allergy to fume or milk thistle;
• acute inflammatory processes in the liver, organs of the biliary system;
• children and adolescents up to 18 years of age.

Terms of sale and storage

The medicine can be bought upon presentation of a prescription from a doctor. Capsules should be stored at temperatures up to 25 degrees for five years from the date of production.

Analogues

The drug is not unique on the market, it can be replaced with several medicines at once. Popular analogues are herbal remedies:

• Allochol - tablets containing activated charcoal, bile, nettle and garlic extract.
• Holosas is a rosehip syrup with hepatoprotective properties.
• Tsikvalon - cholekinetic tablets based on tsikvalon.
• Artichoke extract - tablets and capsules based on the dry extract of the same name.
• Cholagogue collection No. 3 - a mixture of dry herbs: chamomile flowers, tansy and calendula, mint and yarrow leaves.
• Convaflavin - choleretic tablets based on Far Eastern lily of the valley extract.
• Odeston - choleretic tablets containing hymecromon.
• Flamin - choleretic tablets based on the amount of flavonoids of sand immortelle flowers.
• Cholagol - homeopathic drops with choleretic and antispasmodic action, contain turmeric root pigment, franguloemodin, mint and eucalyptus essential oils, magnesium salicylate, olive oil, ethanol.
• Hofitol - tablets and solution based on an extract of field artichoke leaves.
• Karsil - capsules and dragees based on silymarin, obtained from the extract of milk thistle.
• Essentiale Forte - the most popular analogue of Gepabene, contains natural phospholipids to protect the liver.

Gepabene price

You can buy Gepabene in pharmacies or on the Internet with a prescription from a doctor. The cost of the drug depends on the type of manufacturer, the price policy of the seller. Moscow prices for the drug are indicated in the table.