Trittico medicine is available in the form of tablets, which are white with a yellowish tinge. They are oval in shape.
There are two parallel incisors on both sides of the tablet. Each of them contains 75 mg of trazodone hydrochloride.
The auxiliary substances are: magnesium stearate, polyvinylpyrrolidone, carnauba wax and sucrose.
Trittico medicine, even with prolonged use, is not addictive. It does not promote weight gain and is neutral to the uptake of dopamine and norepinephrine.
The main feature of the drug Trittico is a quick effect on mental (fear, irritability, emotional tension, insomnia) and somatic manifestations (symptoms) of anxiety (muscle and headaches, sweating, palpitations, frequent urination, hyperventilation).
This drug has a positive effect on sleep disorders in those people who are depressed. Trittico reduces waking time.
At the same time, the quality of sleep in patients improves.
This drug also perfectly stabilizes the emotional state and improves mood. It is also effective in the treatment of withdrawal symptoms in those patients who are addicted to derivatives such as benzodiazepine and trazodone.
In addition, this medicine helps restore male strength. Whether patients suffer from lingering depression or not.
Mechanism of action
Unlike tricyclic antidepressants and MAO inhibitors, trazodone does not affect monoamine oxidase. The action of trazodone is due to the high degree of affinity of the drug for certain types of serotonin receptors.
Trazodone interacts with them agonistically or antagonistically, and also has the ability to cause blocking of serotonin reuptake. This is confirmed by the instructions attached to the "Trittico" preparation.
The remedy has a quick effect on the symptoms of anxiety, mental and somatic, such as irritability, insomnia, fear, affective tension, headaches, palpitations, increased urination, hyperventilation, sweating and muscle pain.
"Trittico" effectively relieves sleep disorders, increasing its duration and depth, as well as positively affecting its quality and physiological structure. In addition, in chronic alcoholics during the period of abstinence, the drug is able to normalize the emotional background, raise the mood, and reduce the craving for alcohol.
The drug is effective in the treatment of depressive disorders in patients who are addicted to benzodiazepine derivatives. During remission, trazodone should completely replace benzodiazepines.
Another effect of the drug is to increase potency and libido. Moreover, for this purpose, the drug can be used by patients who do not suffer from depressive disorders.
Drug interactions
Before starting treatment with Trittico, you should inform your doctor about all medicines that are taken at the time of prescribing the antidepressant or have been taken within the last two weeks. Otherwise, the specialist will not be able to take into account the specifics of the interaction.
Trazodone is able to increase the intensity of the effects of antihypertensive drugs, therefore, in such a combination, their dosages should be adjusted. When combining drugs with medications that have a depressing effect on the central nervous system, their effect is enhanced.
Antihistamines increase the anticholinergic effect of the drug in question. Patients who use drugs with a high concentration of carbamazepine at the same time as these tablets require careful medical supervision.
Alcohol compatibility
When treating with medication, it is forbidden to use alcoholic beverages.
The drug has a high absorption rate from the gastrointestinal tract. Simultaneous intake of the drug with food slows down the absorption time.
The active ingredient trazodone can enhance the effects of certain antihypertensive medications. In this case, a lower dose of both medicines is required.
When used synchronously with drugs that suppress the central nervous system, the effect of the latter is significantly augmented.
Antihistamine medicine and medicines with anticholinergic efficacy provoke an increase in the anticholinergic effect of trazadone. When taken in parallel with tricyclic stimulants, an increase in the sedative and anticholinergic effect occurs.
When taken simultaneously with MAO blockers and carbamazepine, the likelihood of undesirable effects increases.
Indications for use
Trittico is only used to treat adults. Therapy begins with an appointment once a day in the evening. Increase the daily dose as directed by your doctor. The treatment lasts at least a month.
To minimize side effects, tablets are recommended to be taken after meals. The risks on the tablet allow it to be divided into three parts, if necessary, to gradually increase the dosage.
The instructions for use indicate that adults are prescribed 75 mg per day once in the evening, then increase to a maximum daily dose of 300 mg. Patients on inpatient treatment can increase the dosage to 600 mg per day, necessarily dividing it into several doses.
Elderly patients should avoid single dosages over 100 mg.
The drug should not be administered to adolescents and children. Clinical trials of the effectiveness of Trittico in these categories showed the development of suicidal thinking and behavior, attempts and planning of suicide, aggression and protest behavior.
There are no data on the safety of the drug for children and adolescents, given its effects on puberty, cognitive and behavioral development.
The drug contains sucrose, therefore, Trittico is contraindicated in patients with fructose intolerance, sucrose-isomaltose insufficiency and glucose-galactose malabsorption.
Detailed instructions for the use of Trittico describe how the medicine works and in which clinical cases it is recommended. The drug is prescribed independently or simultaneously with representatives of other pharmacological groups. Medical indications:
- endogenous, psychotic, somatogenic, neurotic depression;
- depressed state against the background of severe pain syndrome;
- anxiety-depressive states with organic lesions of the central nervous system (Alzheimer's disease, dementia, vascular atherosclerosis);
- problems with appetite, eating disorders (anorexia, bulimia);
- chronic insomnia;
- persistent dependence on benzodiazepine drugs;
- phobias, panic attacks, obsessions;
- decreased libido and potency.
The medicine is indicated for the following conditions:
- alcoholic, psychogenic, involutional and other depressions;
- anxiety disorders in Alzheimer's disease;
- senile dementia;
- mental disorders;
- anxiety-depressive states of an endogenous nature;
- cerebral atherosclerosis;
- depressive conditions with prolonged pain syndrome;
- impotence;
- libido disorders;
- dependence on benzodiazepine derivatives.
Trittico is available in 75 and 150 mg tablets.
The drug is taken orally half an hour before meals or at least two hours after. The tablet cannot be chewed; it must be swallowed whole and washed down with plenty of clean water.
Adult patients at the beginning of treatment are prescribed 100 mg one time just before going to bed. Starting from the fourth day of therapy, an increase in dosage up to 150 mg is allowed.
To achieve the maximum effect of therapy with Trittico, the daily dosage should be increased by 50 mg every 4 days until it reaches 300 mg. From 150 mg, the dose should be halved.
Most of it is taken before bedtime, and less in the afternoon. For outpatients, an increase in the maximum daily dosage up to 450 mg is provided, for inpatients it can be 600 mg.
For the treatment of decreased libido, the daily dosage is 50 mg. In the case of monotherapy in the treatment of impotence, it is recommended to take 200 mg per day, with combined therapy - 50 mg.
Therapy for benzodiazepine dependence involves a specific treatment regimen based on a gradual reduction in the dose of benzodiazepine and its replacement with the antidepressant Trittico. Reducing the benzodiazepine dosage by ½ tablet, add 50 mg of trazodone.
The initial daily dosage for the elderly is 100 mg. It can be taken once at bedtime or divided into two doses. Dosage increases should only occur under medical supervision. Most often, there is no need for a daily dosage of more than 300 mg.
Children aged 6 to 18 years are prescribed up to 2 mg per kilogram of body weight per day. Reception is divided into several times a day. The dosage may be increased to 6 mg per kilogram per day.
Contraindications to the appointment of the drug:
- hypersensitivity to the active ingredient of the drug;
- period of pregnancy;
- children under six years of age;
- hepatic or renal impairment;
- a history of priapismoma;
- the manifestation of symptoms of ventricular premature beats;
- arterial hypertension;
- the initial period of remission after a heart attack;
- the presence of tachycardia.
Trittico tablets are prescribed for internal use, 30 minutes before a meal, or four hours after a meal.
It is recommended to use the tablets without chewing, as the integrity of the film shell may be violated. The course of treatment should be started with a dose of 50-100 mg at a time. This amount should be consumed within the first three days of the therapeutic course.
Starting from the fourth day, the dose of the drug must be increased to 150 milligrams per day. Further, the amount of the drug should be increased by 50 mg per day, until the required therapeutic dose is established.
In general, the total daily amount of medication should not exceed 150 mg at a time. The drug use regimens differ depending on the age category of patients:
- Age 18. The daily dose is calculated in the amount of 1-2 mg per body weight. The set amount is divided into several steps. If necessary, the daily amount of medication can be gradually increased every three days to a total dose of 6 mg per 1 kg of body weight.
- Elderly and malnourished patients. The course of therapy for this category of patients begins with a dose of 100 mg per day. Further, the amount of the drug is increased to a total daily dose of 300 mg.
During pregnancy and during breastfeeding, the drug is not recommended for use. For patients with impaired kidney and liver function, the drug is prescribed with extreme caution. Trittico is also not prescribed in childhood (up to six years). When undergoing a course of treatment with this medication, it is not recommended to consume alcohol.
Reviews of doctors and patients who have undergone treatment with Trittico.
From the reviews it is clear that the medication is effective, the only drawback is the frequent manifestation of side effects. Before using the medicine, you must first consult with your doctor.
The drug "Trittico" can also cause negative effects, such as agranulocytosis, leukopenia, anemia, eosinophilia and thrombocytopenia.
The patients complained of allergic reactions.
Diseases of the nervous system are common these days. They are accompanied by depression, stress, insomnia, and other unpleasant symptoms.
To restore the functioning of the nervous system, there are many drugs, including "Trittico".
Patient reviews note that the medicine is effective, normalizes sleep, and soothes.
Composition of the preparation
The drug "Trittico" (reviews of patients pay attention to its seriousness and do not advise taking the drug without consulting a doctor) is produced in the form of tablets, which are packed in a blister of 10 pieces. The package may contain two or six blisters, as well as detailed instructions for the use of the medication.
One pill contains about 150 mg of trazodone hydrochloride. The auxiliary components of the drug include carnauba wax, sucrose, magnesium stearate and povidone.
Pharmacology
The drug "Trittico" belongs to the group of long-acting antidepressants (patient reviews indicate side effects that can develop with prolonged use of pills). The drug is a triazolopyridine derivative. It is characterized by anxiolytic, antidepressant and sedative properties.
The tablets relieve the symptoms of anxiety, which has both somatic and psychological origins.
First of all, it is a feeling of fear, irritability, nervousness, pain in muscles and head, sweating, insomnia and other symptoms.
The medication normalizes the emotional state. Reduces craving for harmful and addictive habits such as alcohol.
"Trittico" can be used in patients with withdrawal symptoms and benzodiazepine dependence. The remedy removes the state of anxiety and depression.
Improves sleep quality. Tablets have a positive effect on libido, potency.
The drug does not develop habituation and does not affect weight gain.
Indications and contraindications
The main indications for the use of the drug "Trittico" (patient reviews believe that the drug relieves hangover syndromes) are depressive and anxious states of various genesis. Doctors recommend this remedy for benzodiazepine addiction, alcohol syndrome, libido disorder, and impotence.
Despite the pronounced effectiveness, the drug is not taken in case of hypersensitivity to this drug and the substances that make up it. It is forbidden to drink these pills for women during pregnancy and while breastfeeding.
Do not drink pills with fructose intolerance, as well as with a diagnosis such as glucose-galactose malabsorption.
Tablets "Trittico": instructions for use
Reviews indicate the need to study the instructions for the drug, since it can cause negative phenomena if used improperly.
According to the instructions, start treatment with a daily dosage of 100 mg. From 1 to 3 days, the drug is taken once, at night. From the fourth day, if necessary, the dose is increased to 150 mg.
In order to obtain the desired therapeutic effect, the dosage is increased gradually, once every 3-4 days. The daily intake of more than 150 mg is divided into two doses.
A smaller dose is drunk at lunchtime, and the main amount of the medication is taken before going to bed.
If the patient is being treated on an outpatient basis, then the daily dosage should not exceed 450 mg (3 tablets), for patients in the hospital, the maximum dose is 600 mg (4 tablets).
The drug is given to children from 6 to 18 years old. Here, the daily dosage is calculated based on 1.5-2 mg / kg of the child's weight. The daily volume is divided into 2-3 doses. To achieve a therapeutic effect, it is allowed to increase the dose to 6 mg / kg. Increase the dose gradually, once every 3-4 days.
Seniors start treatment with 100 mg. If the patient tolerates the drug well, then the daily rate is increased to 300 mg / day. To restore libido, the daily dose is 50 mg. With impotence, the dosage can be up to 200 mg or more, and in complex therapy - 50 mg.
When only Trittico tablets remain in the treatment, they begin to reduce the dosage of this drug once every three weeks. The tablets are drunk whole. They cannot be chewed. The drug is taken half an hour before meals or 2-4 times after meals.
Overdose and side effects
In the note, you will select a list of substitutes. Doctors have published their own ideas about the features of the therapeutic effect in all kinds of diagnoses.
Patients also expressed responses about the individual experience of using the above-mentioned drug prescribed by him. We ask visitors to tell about their practical experience on the current page.
What other medicines for the same indications, in your opinion, are more effective? Do you have any experience of using it in combination with folk methods, therapeutic exercises, physiotherapy? By publishing your own review, you personally will undoubtedly help other patients to get rid of their disease more successfully.
Antidepressant. Trazodone, being a triazolopyridine derivative, has a predominantly antidepressant effect, with some sedative and anxiolytic effects. Trazodone has no effect on MAO, which distinguishes it from MAO inhibitors, tricyclic antidepressants.
The mechanism of action of trazodone is associated with the high affinity of the drug for some subtypes of serotonin receptors, with which trazodone enters into antagonistic or agonistic interactions, depending on the subtype, as well as with the specific ability to cause inhibition of serotonin reuptake.
Quickly affects mental (affective tension, irritability, fear, insomnia) and somatic symptoms of anxiety (palpitations, headache, muscle pain, increased urination, sweating, hyperventilation).
Trazodone is effective for sleep disorders in patients with depression, increases the depth and duration of sleep, restores its physiological structure and quality.
Trittico stabilizes the emotional state, improves mood, and reduces the pathological craving for alcohol in patients suffering from chronic alcoholism during the period of alcohol withdrawal syndrome, also in remission.
With withdrawal symptoms in patients with dependence on benzodiazepine derivatives, trazodone is effective in the treatment of anxiety-depressive states and sleep disorders.
During remission, benzodiazepines can be completely replaced with trazodone.
Promotes the restoration of libido and potency in both depressed patients and those without depression.
The drug is not addictive. It has little effect on the neutral uptake of norepinephrine and dopamine.
Does not affect body weight.
- Psychogenic depression (including neurotic and reactive depression).
- Alcoholic depression.
- Anxiety-depressive states in combination with organic lesions of the nervous system (Alzheimer's disease, dementia, cerebral atherosclerosis).
- Libido and potency disorders.
Inside. The initial dose for adults is 150 mg / day in 2 divided doses: 2/3 of the total daily dose is taken before bedtime (to avoid drowsiness, dizziness), and the rest - in the morning or during the day, in divided doses.
If necessary, the daily dose is increased by 50 mg / day, at intervals of 3-4 days, until an optimal effect is achieved. The maximum daily dose for outpatients is 450 mg, for inpatients - 600 mg.
The initial daily dose for elderly and debilitated patients is 75 mg, if necessary, it can be gradually increased at intervals of 3-4 days, but not more than up to 300 mg. In mild forms of depression, the average maintenance dose is 150 mg / day, in moderate and severe forms - 300 mg / day.
The initial dose for children 6-18 years old is 1.5-2 mg / kg / day in divided doses, if necessary, the dose is gradually increased to 6 mg / kg / day.
In case of violation of libido, the daily dose is 50 mg; in the treatment of impotence in the case of monotherapy - 200 mg / day, in the complex therapy - 50 mg. In the treatment of benzodiazepine drug dependence, the recommended regimen is based on a gradual reduction in the benzodiazepine dose.
Each time the dose is reduced by 1/4 or 1/2 of the tablet, 50 mg of trazodone is added at the same time. This ratio remains unchanged for 3 weeks, then continue to reduce the dose of benzodiazepine until it is completely canceled.
After that, they move on to reducing the daily dose by 50 mg every 3 weeks. Children 6-18 years of age: Initial dose 1.
5-2 mg / kg / day, divided into several doses. If necessary (taking into account tolerance), the dose is gradually increased to 6 mg / kg / day with an interval of 3-4 days.
The drug can cause the following side effects:
- from the nervous system - fatigue, dizziness, agitation, headache, myalgia, weakness, paresthesia, tremor;
- on the part of the circulatory and hematopoietic systems - orthostatic hypotension, bradycardia, decreased pressure, conduction disturbances, arrhythmia; neutropenia and leukopenia;
- from the digestive system - nausea, dry mouth, diarrhea;
- others - eye irritation, allergic reactions.
- Allergy to Trittico tablets.
- Lactation period.
- Pregnancy.
- Age less than 6 years old.
Prescribe with caution to persons with AV blockade, ventricular arrhythmia, myocardial infarction, arterial hypertension, hepatic or renal failure, as well as to persons under 18 years of age, due to the risk of developing suicidal behavior (aggressiveness, suicidal plans, anger).
The drug is contraindicated for use during pregnancy and lactation (breastfeeding).
Trazodone enhances the effect of a number of antihypertensive drugs and requires a decrease in their doses.
Co-administration with drugs that depress the nervous system (clonidine, methylodopa) activates the latter. Antihistamines and anticholinergic drugs enhance the anticholinergic effect of trazodone.
- Psychogenic depression (including neurotic and reactive depression).
- Alcoholic depression.
- Anxiety-depressive states.
- Depressive states with severe pain syndrome.
- Anxiety-depressive states in combination with organic lesions of the nervous system ( alzheimer's disease, dementia, cerebral atherosclerosis).
- Benzodiazepine dependence.
- Libido and potency disorders.
Instructions for use Trittico prescribes to use the drug orally, half an hour before or 2 hours after a meal, without chewing and drinking water.
The initial dose of Trittico is 50–100 mg once a day at bedtime. After 3 days, the dose can be increased to 150 mg per day. A further increase of 50 mg per day can be made every 3 days, until the desired effect occurs. A daily dose of more than 150 mg is divided into 2 doses, a smaller dose is taken in the afternoon, and a large dose at bedtime.
The maximum daily dose in stationary conditions is 600 mg, in outpatient conditions - 450 mg.
Children aged 6-18: The initial dose of 1.5 mg per kilogram of body weight per day is divided into several doses. If necessary, the dose is increased to 6 mg per kilogram of body weight per day.
Elderly and weakened persons: the initial dose is up to 100 mg per day. If necessary, you can increase the dose to 300 mg per day.
Therapy for libido disorders: daily dose of 50 mg.
Erectile dysfunction therapy: with monotherapy, the daily dose is up to 200 mg, with combined therapy - 50 mg.
Contraindications
Trittico is prescribed for the treatment of depressive disorders. The drug is effective in relation to depressive episodes, including for the prevention of their recurrence. It can be used to replace other SSRI drugs, the effectiveness of which is insufficient. It is taken to eliminate anxiety amid depression.
Contraindications to the use of Trittico are:
- known drug intolerance;
- alcohol poisoning;
- poisoning with sleeping pills;
- acute phase of myocardial infarction.
Before use, a mandatory consultation with a doctor is required, who will take into account the individual characteristics of the course of the pathology and the existing contraindications.
Oral administration of Trittico tablets is not approved for all patients. The instructions for use describe a complete list of medical contraindications:
- pregnancy;
- alcohol intoxication;
- lactation;
- age up to 6 years;
- hypersensitivity of the body to the components of the drug.
The chemical composition contains sucrose, therefore, tablets are contraindicated in patients with glucose-galactose malabsorption, sucrose-isomaltose insufficiency. There are relative medical contraindications. Trittico tablets are prescribed with caution for such diseases:
- complications of renal and hepatic failure;
- chronic tachycardia;
- ventricular arrhythmia;
- transferred myocardial infarction;
- patients with AV block;
- arterial hypertension;
- age up to 18 years.
The medicine is not prescribed:
- with depressive disorders in patients under 6 years of age;
- during breastfeeding and pregnancy;
- with increased sensitivity to the components of the drug.
With caution, the medication is prescribed for such conditions and pathologies:
- arrhythmia of the ventricles;
- liver failure;
- AV block;
- priapism;
- renal failure;
- arterial hypertension;
- myocardial infarction and rehabilitation after an attack;
- adolescence.
The indications for the appointment of Trittico tablets are:
- Anxiety-depressive disorders of the endogenous type. This also includes involutional depressions.
- Neurotic and reactive psychogenic depression.
- Depressive disorders as a consequence of pathologies of the central nervous system: atherosclerosis, Alzheimer's disease, dementia, etc.
- Depression against the background of prolonged pain syndrome.
- Alcoholic depressive disorders.
- Violations of potency and libido, including against the background of depression.
- Benzodiazepine dependence.
According to the instructions, "Trittico" is contraindicated in the following cases:
- Pregnancy and lactation.
- Children under the age of 6.
- Individual intolerance to the components of the drug.
Prescribing the drug to children under the age of 18 should be done with the utmost care. For elderly and debilitated patients, it is necessary to select an individual dosage regimen.
Starting from the minimum dose, it can be increased, depending on how the patient's body reacts to therapy. Usually, a sufficient daily dose of Trittico tablets is 300 mg.
- disorders of potency and libido, including those caused by depressive conditions;
- benzodiazepine dependence;
- depressive conditions, accompanied by high anxiety against the background of diseases of the central nervous system (Alzheimer's disease, dementia, cerebral atherosclerosis);
- alcoholism;
- psychogenic depression;
- violation of the emotional state due to prolonged pain syndrome;
- alcoholic depression.
Do not use Trittico in the following cases:
- lactation period;
- pregnancy;
- high sensitivity to the main and / or additional components of the drug.
It is necessary to take this product with special care by persons who drive a vehicle, since a loss of concentration is not excluded.
Trittico is not prescribed for children under 6 years of age. It is prescribed with caution when:
- atrioventricular block;
- episodes of priapism in history;
- ventricular arrhythmias;
- myocardial infarction;
- postinfarction period;
- arterial hypertension;
- liver failure;
- heart problems;
- renal failure.
Prescribe with caution to persons with AV blockade, ventricular arrhythmia, myocardial infarction, arterial hypertension, hepatic or renal failure, as well as to persons under 18 years of age, due to the risk of developing suicidal behavior (aggressiveness, suicidal plans, anger).
Trittico price
In Russia, the price of Trittico 150 mg No. 20 is 391-515 rubles, and in Ukraine it will cost 217 hryvnias to buy a drug of the same dosage.
Alcoholism is a rather serious problem that must be dealt with in a timely manner. For this purpose, medications are often used. Quite effective, in this case, is Trittico, reviews of which are only positive.
Composition and action of the drug
Trittico, the instructions for which are attached in the package, are produced in the form of tablets that are white. The main component of the drug is trazodone hydrochloride. Also, the medication is developed on the basis of magnesium stearate, carnauba wax, polyvinyl pyrolidone and sucrose.
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Due to the universal composition of the drug, even with its long-term use, addiction is not observed in patients. The drug is unable to capture dopamine and norepinephrine. That is why, during the period of using the drug, there is no increase in the patient's body weight.
Alcohol addiction
The drug Trittico is characterized by the presence of active thymoleptic and anxiolytic action. With its help, the depth and duration of sleep is increased during the period of alcoholism therapy. The action of the drug is aimed at reducing the pathological craving for ethanol. With the help of the medicine, anxiety-depressive conditions are eliminated.
Our regular reader shared an effective method that saved her husband from ALCOHOLISM. It seemed that nothing would help, there were several codings, treatment at the dispensary, nothing helped. The effective method that Elena Malysheva recommended helped. EFFECTIVE METHOD
Trittico successfully combats such manifestations of anxiety as fear, tension, insomnia and irritability. And also with headache, myalgia, frequent urination and increased sweating. The drug has a good effect on sleep, normalizes it, increasing the duration and depth of sleep. The drug restores sexual desire and potency, stopping the craving for ethanol.
Indications and contraindications
The use of the drug Trittico should be carried out only in accordance with the indications, which will ensure the maximum effectiveness of the treatment:
Despite the high efficiency and a large number of reviews about Trittico, the medication is characterized by the presence of certain contraindications.
It is strictly forbidden to take medicine for patients with tachycardia. The use of medication for arrhythmias is not recommended. For female representatives during the period of bearing a child, medicine is prohibited. If a woman is breastfeeding a newborn baby, then she is not recommended to use a medication. With hypersensitivity or complete intolerance to the components of the medication, its use is strictly prohibited.
In renal and hepatic insufficiency, medication should be treated as carefully as possible. If a patient has a history of priapism, then taking the medication is allowed only after consulting a doctor. With atrioventricular block, medication is not recommended. If a person is diagnosed with arterial hypertension, then it is allowed to use the medicine only after consulting a doctor. With myocardial infarction, drug treatment is carried out very carefully.
In order to avoid the appearance of undesirable effects, during the period of use of the drug, it is imperative to take into account the indications and contraindications. In this case, analogs are used, since these drugs have a different composition.
Unwanted effects
The antidepressant is characterized by the absence of anticholinergic action. That is why its use is permitted by elderly patients. The drug is characterized by the absence of negative effects on the body if the patient has angle-closure glaucoma or pancreatic hypertrophy. Despite this, the medication is characterized by the presence of certain undesirable effects:
- Taking the wrong medication can lead to increased agitation.
- Some patients complain of bitterness in the mouth.
- Undesirable effects can manifest as excessive sleepiness and increased fatigue.
- If the medication is taken incorrectly, hypotension can be diagnosed, as well as allergies, which have a variety of clinical manifestations on the skin.
- Taking medicine may be accompanied by arrhythmias, as well as dizziness.
- Sometimes patients experience severe weight loss, up to anorexia.
- Adverse effects can manifest as disorientation or severe pain.
- After taking the medication, patients may be diagnosed with neuropenia or sialgia.
- Patients often complain of nausea and vomiting after taking the medication.
- Some of the patients are diagnosed with leukopenia or bradycardia.
- Side effects in some cases are manifested by limb tremors or eye irritation.
Most of the side effects in patients are observed while taking the medication in excessive amounts. In order to avoid the appearance of undesirable effects, before taking the medication, you must consult your doctor. If the patient observes adverse reactions, then the drug must be canceled.
Application features
The antidepressant should be used according to a strictly established scheme in compliance with the dosage. The prescription of the medication is carried out by the doctor in accordance with the indications and individual characteristics of the patient. Before prescribing a medication, an examination of the patient is mandatory. A blood test directly affects the dosage of the drug. With a deficiency of leukocytes, taking medication in large doses can lead to a worsening of the condition. This is due to the fact that the action of the drug is aimed at reducing the number of leukocytes.
Patients are strictly prohibited from using the medication on their own. They must remember that Trittico and pregnancy are incompatible concepts. That is why it is strictly forbidden to take medicine in this position for the fairer sex. In most cases, the drug is initially prescribed in high doses, which are gradually reduced. This allows you to eliminate the side effects that may occur during the period of taking the medication.
The medication should be taken twice a day. Since taking the pills can lead to dizziness, it is recommended to drink the drug before bedtime. If the need arises, then the daily dose of the medication can be increased by the doctor. If the patient is treated in a stationary environment, then he can take a large dose of the drug per day.
If the patient is of advanced age or weakened immunity, then the daily dose of the drug will be much less than that of an ordinary person. If a person is diagnosed with mild forms of depression, then the medication is taken for prevention purposes. In this case, it is necessary to take breaks between taking the medication for two days.
If the patient has alcohol dependence, then the medication should be taken 30 minutes before a meal or a few hours after it. Gradually, the doctor is increasing the dosage of the medication. During the period of taking the tablets, it is strictly forbidden to chew them. They should be washed down with plenty of water.
Trittico and alcohol
Is it possible to take medicine and alcohol at the same time? During the period of alcohol intake, blood pressure rises significantly. If you take the drug at the same time, it will help to lower it. That is why, while taking medication and alcoholic beverages, a lack of oxygen in the blood is often observed - hypoxia.
Dizziness
Such medication will lead to a sharp deterioration in the state of human health. In most cases, patients experience dizziness. In some cases, patients experienced syncope. If you drink alcohol and an antidepressant at the same time, the first of them will slowly oxidize in the body. This action is the cause of serious poisoning. Quite often, while taking alcoholic beverages and medicines, there are malfunctions in the performance of the nervous system.
The state of health of patients worsens significantly, they become lethargic. With the further use of alcoholic beverages, the situation is aggravated. In some cases, breathing disorder may occur, as well as the development of a coma. If a person consumes alcohol during the treatment period, then this negatively affects the liver and contributes to its destruction. The appearance of complete intoxication of this organ was also observed. Such treatment can lead to the development of complex forms of toxic hepatitis. To avoid this, it is necessary to use analogues or completely abandon alcohol.
Trittico tablets belong to the category of highly effective drugs that are used to treat alcoholism. Due to the universal composition of the drug, it stabilizes the psychological health of the patient. The drug Trittico affects the reaction rate and also has a sedative effect. Due to the presence of side effects, the drug must be taken very carefully.
Why is Trittico prescribed? Let's take a closer look at this article.
Depression is a mental disorder that is characterized by thinking failures, motor retardation, and decreased mood. Many people do not consider depression to be a number of diseases and do not consider it dangerous, but this is a common misconception. This is a serious and dangerous pathology of the psyche that causes passivity and depression in a person.
Signs of pathology
Depression is characterized by decreased self-esteem, apathy, and deep indifference to one's life and the world around them. Quite often, a depressed person finds addiction to alcohol and drugs. However, this method does not solve the problem and does not remove the cause of the depressive state, but only relieves the symptoms. In addition, alcohol and drug use exacerbates a person's mental state, making them lost.
Depression as a mental disorder is more common among females; men rarely become victims of this disease. People between the ages of 18 and 55 are at greatest risk of becoming depressed, but in rare cases, the disorder may develop earlier or later.
Views
The disease is divided into certain types depending on the reasons for its occurrence:
Treating depressive disorders is necessary, as the lack of help can lead to consequences in the future. This will not only seriously affect human health in general, but can also develop into more serious mental pathologies. The pharmaceutical market offers a wide range of drugs aimed at treating and relieving symptoms of depression. Among them, doctors often prescribe Trittico, an antidepressant trazodone, a triazolopyridine derivative. The drug creates an antidepressant effect, simultaneously exerting an anxiolytic and sedative effect on the body. Reviews about Trittico abound.
Mechanism of action
Unlike tricyclic antidepressants and MAO inhibitors, trazodone does not affect monoamine oxidase. The action of trazodone is due to the high degree of affinity of the drug for certain types of serotonin receptors. Trazodone interacts with them agonistically or antagonistically, and also has the ability to cause blocking of serotonin reuptake. This is confirmed by the instruction attached to the Trittico preparation.
The remedy has a quick effect on the symptoms of anxiety, mental and somatic, such as irritability, insomnia, fear, affective tension, headaches, palpitations, increased urination, hyperventilation, sweating and muscle pain.
"Trittico" effectively relieves sleep disorders, increasing its duration and depth, as well as positively affecting its quality and physiological structure. In addition, in chronic alcoholics, during the period of abstinence, the drug is able to normalize the emotional background, improve mood, and reduce the craving for alcohol. The drug is effective in the treatment of depressive disorders in patients who are addicted to benzodiazepine derivatives. During the remission period, trazodone should completely replace benzodiazepines. Another effect of the drug is to increase potency and libido. Moreover, the drug can be used for this purpose by patients who do not suffer from depressive disorders.
According to reviews, there is no addiction to Trittico. It does not affect the uptake of dopamine and norepinephrine or weight gain.
Structure
One tablet contains 150 mg of trazodone hydrochloride and excipients (sucrose, lovidone, carnauba wax and magnesium sterate).
The drug has a high degree of absorption from the gastrointestinal tract. It is impossible to use the drug with food or immediately after, as this slows down the absorption. In the liver, the active substance is metabolized. 75 percent of metabolites are excreted by the kidneys. Complete elimination of the drug from the body occurs 98 hours after administration.
Indications
The indications for the appointment of Trittico tablets are:
- Anxiety-depressive disorders of the endogenous type. This also includes involutional depressions.
- Neurotic and reactive psychogenic depression.
- Depressive disorders as a consequence of pathologies of the central nervous system: atherosclerosis, Alzheimer's disease, dementia, etc.
- Depression against the background of prolonged pain syndrome.
- Alcoholic depressive disorders.
- Violations of potency and libido, including against the background of depression.
- Benzodiazepine dependence.
Side effects
According to reviews, the following conditions can become side effects from taking the drug "Trittico":
- Drowsiness.
- Fast fatiguability.
- Headache.
- Nervous excitement.
- Dizziness.
- Myalgia.
- Weakness.
- Discoordination.
- Disorientation.
- Tremor.
- Paresthesias.
- Decrease in blood pressure.
- Arrhythmia.
- Orthostatic hypotension as a consequence of the adrenolytic effect of taking the drug.
- Bradycardia.
- Neutropenia and leukopenia.
- Violation of conductivity.
- Feeling of bitterness in the mouth and dryness.
- Diarrhea.
- Nausea and vomiting.
- Allergic reactions.
- Decreased appetite.
- Eye irritation.
- Priapism.
The appearance of these symptoms is a reason to stop taking the drug and consult your doctor.
Contraindications
According to the instructions, "Trittico" is contraindicated in the following cases:
- Pregnancy and lactation.
- Children under the age of 6.
- Individual intolerance to the components of the drug.
Prescribing the drug to children under the age of 18 should be done with the utmost care. For elderly and debilitated patients, it is necessary to select an individual dosage regimen. Starting from the minimum dose, it can be increased, depending on how the patient's body reacts to therapy. Usually, a sufficient daily dose of Trittico tablets is 300 mg.
Instructions for use
Trittico is available in 75 and 150 mg tablets.
The drug is taken orally half an hour before meals or at least two hours after. The tablet cannot be chewed; it must be swallowed whole and washed down with plenty of clean water.
Adult patients at the beginning of treatment are prescribed 100 mg one time just before going to bed. Starting from the fourth day of therapy, an increase in dosage up to 150 mg is allowed. To achieve the maximum effect of therapy with Trittico, the daily dosage should be increased by 50 mg every 4 days until it reaches 300 mg. From 150 mg, the dose should be halved. Most of it is taken before bedtime, and less in the afternoon. For outpatients, an increase in the maximum daily dosage is provided to 450 mg, for inpatients it can be 600 mg.
For the treatment of decreased libido, the daily dosage is 50 mg. In the case of monotherapy in the treatment of impotence, it is recommended to take 200 mg per day, with combined therapy - 50 mg.
Therapy for benzodiazepine dependence presupposes a specific treatment regimen based on a gradual decrease in the dose of benzodiazepine and its replacement with the antidepressant Trittico. Reducing the benzodiazepine dosage by ½ tablet, add 50 mg of trazodone. Further three weeks nothing changes, then the reduction of benzodiazepine continues until it is completely canceled. Once this point is reached, a gradual withdrawal of 50 mg trazodone every three weeks begins.
The initial daily dosage for the elderly is 100 mg. It can be taken once at bedtime or divided into two doses. Dosage increases should only occur under medical supervision. Most often, there is no need for a daily dosage of more than 300 mg.
Children aged 6 to 18 years are prescribed up to 2 mg per kilogram of body weight per day. Reception is divided into several times a day. The dosage may be increased to 6 mg per kilogram per day.
Interaction with other drugs
"Trittico" reduces the effect of certain antihypertensive drugs, which may require a reduction in their dosage.
The effects of drugs such as methyldol and clonidine, which can depress the central nervous system, are also enhanced when taken with trazodone.
Antihistamine drugs with anticholinergic activity increase the effectiveness of trazodone.
Trittico and alcohol are incompatible. This leads to hypoxia and a deterioration in general well-being.
The drug prolongs and enhances the anticholinergic and sedative effect of taking tricyclic antidepressants, loxapine, haloperidol, phenothiazine, thioxanthene, limoside and maprotiline.
Concomitant use of trazodone with MAO inhibitors significantly increases the risk of adverse reactions. This combination, among other things, increases the accumulation of phenytoin and digoxin in the blood plasma.
It also interacts with substances such as ritonavir, indinavir, ketoconazole, and fluoxetine. These components increase the concentration of trazodone in the blood. The drug "Trittico" analogs should be selected by a doctor.
special instructions
Since the drug is capable of exhibiting a certain adrenolytic activity, against the background of its administration, bradycardia may appear, as well as a decrease in blood pressure. For this reason, its appointment to patients with problems of the cardiovascular system should be carried out with an assessment of the possible risks. The same applies to patients with recent myocardial infarction, cardiac conduction disturbances and AV block of varying severity.
Taking the drug "Trittico" can cause a slight decrease in the level of leukocytes in the blood, but this phenomenon does not need special treatment, unless it reaches a level of pronounced leukopenia.
During the course of therapy with this drug, it is necessary to regularly conduct a microbiological blood test, especially if you have a sore throat or fever. The side effects of Trittico are described in detail above.
The drug has no anticholinergic effect. Therefore, it can be taken by older people who have a history of prostatic hypertrophy, cognitive impairment, or angle-closure glaucoma.
Available only by prescription. Unreasonable or too prolonged erections are the reason for seeking medical attention. The use of alcohol during the period of therapy is prohibited.
Since the drug has an anxiolytic and sedative effect, a decrease in attention and speed of psychomotor functions may occur. Therefore, for the duration of therapy, it is better to give up driving vehicles, controlling high-precision mechanisms and other hazardous activities.
Depression is a mental disorder in which a person loses a sense of reality. It manifests itself in the form of apathy, irritability, confusion of consciousness, loss of mood, etc. In fact, depression is a rather serious disease that can hardly be overcome on its own.
Trittico is an effective antidepressant that relieves symptoms of depression. We will describe the properties and indications of the medication in our article.
Another name is Trazadon. It is this substance that is the active component of the medication. The tablets contain 150 mg trazadone hydrochloride. The following components are used in the tablet formula:
- sucrose;
- carnauba wax;
- magnesium stearate;
- povidone.
Trittico 150 has antidepressant properties. This drug is considered to be a more gentle agent, since there is no effect on MAO, which cannot be said about tricyclic antidepressants. The drug, when ingested, almost immediately affects the psychogenic and somatic signs of anxiety, which are expressed in:
- irritability;
- insomnia;
- fear, unreasonable tension;
- headache and muscle pain;
- frequent urge to use the toilet, etc.
Trazodone reduces the craving for alcohol, improves mood, and also enhances erection and libido. The active substance of the drug causes the suppression of the reuptake of serotonin (the hormone of joy).
Release form
Trittico is available in tablet form. Oval tablets, with a yellowish or white color. Medicinal dosage:
- 75 mg of active ingredient. Packs of 15 or 30 tablets;
- 150 mg of active ingredient. 10 or 20 tablets in one package.
Expert opinion
Trazodone should not be self-administered. Although the drug is well tolerated by the body, however, if the antidepressant medication is incorrectly selected, the symptoms of the disease may worsen. The active active ingredient locally affects the psychosomatic functions of a person.
The drug Trittico helps in mild forms of depressive disorder. Also, the medication is prescribed for the treatment of erectile dysfunction in men. However, without a specialist's testimony, you should not take pills. The effectiveness of Trittico depends on the correctly prescribed dosage, which may differ from the instructions for use.
Instructions for use of Trittico
The antidepressant has long been used in psychiatric practice. It is prescribed for the treatment of depressive conditions, recurrent and initial, mental disorders, including anxiety, fear, confusion of thinking.
Indications for use
- Depression of various etiologies (mental, endogenous, neurotic), complicated by a feeling of fear and anxiety;
- Dysfunction of the reproductive system in men (decreased potency, decline in libido at the psychogenic level);
- Alcohol depression.
List of contraindications
- hypersensitivity to the components of the product;
- chronic alcoholism;
- intoxication with alcohol or sleeping pills.
Major side effects
Trazadone has a wide range of side effects, but mostly they appear when the drug is taken incorrectly:
- dizziness, drowsiness, confusion;
- tachycardia, tremors, convulsions;
- from the digestive tract: dryness in the mouth, stomach pain, frequent thirst, heaviness in the stomach, intestinal atony;
- hypotension.
Influenza-like symptoms (fever, nasal congestion, fatigue) are rare.
Trittico: overdose
Do not exceed the dose indicated in the instructions. If more pills are taken, then the patient will develop signs of an overdose, which are expressed in increased side effects. Hallucination, apathy, aggressiveness, nausea and vomiting may also join. If signs of overdose are detected, you should immediately stop taking the medication and consult a specialist.
Compatibility with other drugs
The active substance trazadone enhances the therapeutic effect of antihypertensive drugs, which results in an excessive decrease in blood pressure. This is fraught with the formation of vascular collapse. The intake of Trittico tablets and hypertensive drugs should be adjusted with the attending physician and the therapist should be notified in advance about taking the antidepressant to prescribe the optimal dose of the drug.
The drug does not work well with tricyclic antidepressant medications. The likelihood of side effects from the cardiovascular system is high. Moreover, Trittico cannot be combined with MAO inhibitors, since a severe form of side effects is manifested, which is equivalent to a severe overdose.
Alcohol compatibility is excluded. While taking the medication, alcohol is excluded even in the minimum dosage.
special instructions
For the first couple of weeks, the patient should be under the supervision of the attending physician, since often, when the drug is prescribed, the patient's symptoms of a depressive state are aggravated. The same applies to patients who have been identified with suicidal tendencies.
Patients with epilepsy should not reduce or exceed the prescribed dose without notifying the treating doctor. In some cases, it is better to give up driving a car and not use equipment that requires increased concentration.
The modern way of life often leads to disturbances in the activity of the central nervous system.
The fast pace of life, stressful situations - all this adversely affects the mood. Sometimes a doctor may prescribe medications for depression.
When it is necessary to take medicine for a long time, patients are interested in whether it is possible to combine Trittico and alcohol. , which is worth knowing in advance.
Features of the drug
You can assess how Trittico and alcohol are combined if you consider the mechanism of action of the drug.
The tool belongs to the category of antidepressants. It is used in the treatment of depressive conditions, sleep disorders, and unreasonable anxiety.
Trittico - an antidepressant aimed at disrupting the mechanism of serotonin reuptake
The peculiarity of the drug is its speed of action. The effect can be felt within a week after the start of treatment. A muscle relaxant antidepressant has a sedative and calming effect by disrupting the serotonin reuptake mechanism.
Distinctive features of the medication are as follows:
- the agent does not lead to an increase in body weight;
- relieves attacks of anxiety and fear;
- eliminates insomnia;
- improves the quality of sleep;
- relieves irritability;
- reduces headache;
- fights tremors of the limbs;
- helps with the nervous urge to urinate.
The medication does not affect the amount of hormones in the human body. Metabolism proceeds at a normal rate.
Daytime sleepiness decreases with the use of Trittico. The depth of night sleep increases and the person feels rested.
Sometimes the medication is prescribed to patients with behavioral disorders, phobias and manias. Do not use the drug in children under 18 years of age, pregnant women and suffering from hepatic and renal insufficiency.
Active components of the drug
Before combining Trittico and alcohol, you should consult with your doctor. It will help you understand why it is not recommended to combine these substances.
Trazodone - the structural formula of the active substance of the drug Trittico
Trittico contains trazodonoma hydrochloride. Each tablet contains 75 or 150 mg, depending on the dosage.
Additional components are as follows:
- sucrose;
- magnesium stearate;
- wax;
- povidone.
The effect of the drug persists for some time after discontinuation of the drug. The medicine is quickly absorbed and well distributed throughout the body.
After 4 hours, the maximum concentration of the active component is reached in the blood. The half-life of the substance is 12 hours. Metabolism - in the liver. Excretion - with urine.
Medical indications for the use of a medication
Taking Trittico and alcohol may be prohibited for medical reasons.
The medicine is prescribed in the presence of the following conditions and diseases:
- depression;
- phobias;
- nervousness;
- irritability;
- anxiety;
- apathy;
- impotence;
- cerebral atherosclerosis;
- dementia;
- bulimia;
- periodic migraines.
Sometimes Trittico is used to combat an existing one. Do not use without a doctor's prescription.
Refuse to use the drug Trittico should be in the presence of the following conditions:
- hypersensitivity to the components of the product;
- tendency to tachycardia;
- hypertonic disease;
- renal and hepatic impairment;
- ventricular premature beats;
- a history of a heart attack.
You can protect the body from an adverse reaction if you take into account the existing contraindications and take the drug strictly according to the scheme recommended by the doctor.
Compatibility of Trittico and alcoholic beverages
An analysis of the effect of both substances on the body will help to decide whether to combine Trittico and alcohol or not. ...
This medication also affects this area. There is no compatibility between Trittico and alcohol. The combination can provoke adverse reactions.
Under the influence of alcoholic beverages, the effect of the medication is enhanced. It is difficult to estimate which dosage will be optimal. If you combine Trittico and alcohol, the consequences can be unexpected.
Potential consequences from incorrect alignment
It is impossible to combine Trittico and alcohol.
This can lead to the development of the following symptoms:
- anemia;
- agranulocytosis;
- allergy;
- violation of the production of vasopressin;
- decreased appetite;
- suicidal tendencies;
- hallucinations;
- nightmares;
- aggressiveness;
- convulsions;
- memory impairment;
- a heightened sense of anxiety;
- arrhythmia;
- bradycardia;
- violation of the ECG picture;
- dyspnea;
- drops in blood pressure;
- impaired liver function;
- myalgia;
- violation of urination.
Under no circumstances should Trittico be taken after alcohol. This causes severe negative symptoms and exacerbation of the existing disease.
Conclusion
Combining treatment with Trittico and drinking alcohol is prohibited.
This negatively affects the functioning of the central nervous system, can intensify symptoms and slow down the body's recovery from illness.
Video: Effectiveness of Trittico
