Trittico for alcohol addiction. Trittico instructions for use, contraindications, side effects, reviews

30.12.202027.05.2017

Trittico belongs to pharmaceutical products based on thiazolopyridine. This automatically classifies the pills as a muscle relaxant antidepressant.

From a chemical point of view, the effect on the body is achieved through the reuptake of the hormone of happiness. This approach became possible due to the fact that the sedative algorithm was based on the relationship with serotonin receptors.

Practical effectiveness

Numerous positive reviews confirm the effectiveness of this method of treatment. But there is one nuance here. Experts insist that only the original drug is used for therapy. It can be recognized by some external signs, as well as by the photo of the package.

An antidepressant is produced in tablets, which makes it highly popular among patients, because it is much easier to use such a medication than to go to the hospital for injections every day. This form of release also provides for a pair of parallel incisors on each side of the tablet, which is yellowish in color.

The active ingredient is trazodone hydrochloride, but in addition to it, the composition provides for several more auxiliary components. They are aimed at ensuring that the membrane is not damaged until the drug enters the stomach for subsequent dissolution.

Against the backdrop of numerous analogues, Trittico boasts one significant advantage. It is about the speed of exposure to the body. The instructions for use claim that with the help of the medicine it will be possible to get rid of not only the usual irritability and feelings of fear. Patients lose affective tension and insomnia goes away.

And this is not to mention the somatic signs that usually haunt overly impressionable individuals. In such people, anxiety can end with physical manifestations of anxiety, including headaches, unpleasant sensations in the muscles, increased sweating, rapid heartbeat, and frequent urination.

The main indications even include prescriptions for those suffering from sleep disorders with prolonged depression. This is due to a decrease in the period of wakefulness in favor of improving the quality of sleep.

The medicine is also well suited for those who need to stabilize their emotional state. It can even help improve your mood. Due to all of the above, Trittico is often used by specialists who treat the dependence of certain chemicals, such as:

benzodiazepine;
trazodone.

An additional advantage here will be the restoration of male strength, and this does not depend on the presence of depression.

What to look for

Like any other product in the pharmaceutical industry, this drug has its own side effects. Due to the high risk of becoming a victim of them, doctors remind that self-medication in a particular case is almost akin to suicide. Hence the natural desire of doctors to prevent attempts by patients to independently prescribe a course of treatment for themselves with such a remedy.

Before using the substance, the patient will need to undergo a clinical examination. Based on its results, it will be possible to deduce the ideal treatment period. In the same way, the exact dosage will become known, which is suitable for a specific person, depending on his:

floor;
age;
current health status;
possible chronic diseases.

Due to its productivity, the drug has received international recognition, since the list for its indications is quite wide, and contraindications are considered standard. If you act according to the rules, then you can count on a good result without significant harm to the body.

Usually, the mechanism of action presented is great for those who suffer from:

disorders of potency or problems with libido;
dependence of the benzodiazepine type;
certain types of depression;
alcoholism and subsequent depression after it;
destabilization of emotional balance due to significant pain syndrome.

It is important to remember that during rehabilitation therapy, the dosage prescribed on the basis of doctors' research should not be changed in any direction. This is especially true in cases when it seems as if the relief comes for a long time, and the patient wants to accelerate the onset of a positive effect.

Also, one should not lose sight of the main contraindications, which provide for the refusal of such therapy when:

pregnancy;
lactation;
allergies or individual intolerances.

Although the drug can be drunk by mental workers, it is not recommended for drivers to take it. There remains a high risk of loss of concentration during prolonged monotonous activity, because a person simply begins to fall asleep.

Even a short-term course of admission is not prescribed for babies until the age of six. The developers emphasize that the tool has, in addition to a number of standard contraindications, so-called relative precautions. This means that it is prescribed with extreme caution to people whose medical records contain one of the serious diseases such as liver failure. A complete list of relative contraindications can be found in the instructions, or check directly with your doctor.

Thanks to the gentle active ingredient, such treatment can be recommended even for people of retirement age who have encountered a number of ailments inherent in age-related deviations.

Side effects

Usually, the side effects when using Trittico are very mild. Strengthening the effect can be achieved only when the dosage is exceeded, or because of the individual characteristics of the organism. But, regardless of the reason that prompted the deterioration of health, you should immediately stop taking the pills. Otherwise, the consequences will be significant.

The description of side effects provides a classic picture for pharmaceuticals of this focus:

drowsiness;
fatigue;
bitterness in the mouth;
headache;
arrhythmia;
dizziness.

Atypical or rare side effect symptoms are possible. In order not to miss this, in case of any deviation of health indicators, it is imperative to report them to the attending physician. If the condition has deteriorated sharply, it is better to call an ambulance and tell the doctor on duty the name of the medication.

Alcoholic combination

Since Trittico is sometimes used to cure alcoholism, some naively believe that the active substance and alcohol are quite compatible things. But in practice, this interaction has the opposite effect.

The reason for such a harsh ban lies in the fact that alcoholic beverages usually increase blood pressure, while the drug works in the opposite way. When these two components enter the bloodstream, the body will not be able to "understand" what it needs to do in this case, which will bring the victim to the rapid development of hypoxia.

After the tissues no longer receive enough oxygen for normal functioning, the victim will begin to suffer from prolonged dizziness. To avoid this, you just need to strictly adhere to the doctor's recommendations.

stopalkogolizm.ru

Trittico is a high-quality muscle relaxant antidepressant, which is a tablet with a substance derived from thiazolopyridine. The sedative and calming effect occurs as a result of the drug's affinity for serotonin receptors, which prevents the reuptake of the so-called "happiness hormone".

The medicine does not affect the metabolism and concentration of other hormones, does not increase body weight, eliminates irritability, anxiety, fear and insomnia, suppresses somatic manifestations of stress, such as excessive sweating, tremors of the limbs, relieves headaches, and reduces the urge to urinate. Trittico has an extremely beneficial effect on the quality of sleep, enhances its depth, regulates the duration, and relieves daytime sleepiness. The drug does not affect sexual function and helps to restore it.

The main indicator of the success of the drug is its accelerated action, 50% of people feel significant relief in the first week. The drug helps to cope with eating disorders, kleptomania, various manias and phobias. Not recommended for people with cardiovascular disease, kidney or liver failure, pregnant and lactating women, children under 18 years of age. Can I drink trittico with alcohol? Most likely no.

Symptoms of poisoning or drug overdose may include excessive sleepiness, disorientation, nausea, and exacerbation of heart problems. Under no circumstances should Trittico be taken after alcohol. Even low alcohol drinks and beer are prohibited. After the full course of treatment, it should be kept for about three more weeks before looking into the bottle.

Trittico and alcohol, the consequences of which often turn into a serious problem for the patient, are not the best couple. And primarily because this medicine is prescribed for the rehabilitation of chronic alcoholics. Even a drop of alcohol can negate long-term treatment and allow a person to break free after temporary abstinence.

Therefore, it is worth remembering firmly: the compatibility of Trittico with alcohol is the lowest. The interaction of trittico with alcohol completely cancels the beneficial effect of the active substances of the drug and returns the patient to the initial stage of the fight against symptoms.

med.otvetov.ru

Description of the drug

The tablets are white with a yellowish tinge and have an oval shape. Each of them contains a strict amount (75 mg) of trazodone hydrochloride. The auxiliary components are: carnauba wax, magnesium stearate, sucrose, polyvinylpyrrolidone.

Pharmacists note that even with prolonged use of this pharmacological drug, it is not addictive.

Trittico tablets are completely neutral to the capture of norepinephrine and dopamine. Therefore, those taking the medication do not have to worry about weight gain.

It has an active thymoleptic and anxiolytic effect on the patient's body.
Increases the depth and duration of patients' sleep during treatment
Reduces the pathological craving for ethanol decreases with proper intake.
Eliminates anxiety and depression.

Indications and contraindications

The drug Trittico is indicated for use in the following cases:

Benzodiazepine dependence.
Depressive conditions, which are accompanied by increased anxiety against the background of Alzheimer's disease, dementia or atherosclerosis of the cerebral vessels.
Disruption of the normal emotional state due to prolonged pain syndrome.
Alcoholism (acute alcoholic syndrome) and psychogenic depression.
Libido and potency disorders that could be triggered by depressive disorders.
Increased fatigue and slowed down thinking.
Bulimia, phobias.
Constant acute migraine attacks.
Suicidal attempts.

Contraindications include:

Pregnancy and lactation period.
Hypersensitivity or complete intolerance to the components of the product.
Arrhythmia and tachycardia.

Trittico tablets should be taken with extreme caution for the following diseases:

Renal and hepatic impairment.
Arterial hypertension.
Atrioventricular block.
A history of priapism.
Myocardial infarction.

Care should be taken when taking these tablets after a recent heart attack, as they can adversely affect the work of the heart.

Trittico tablets do not have an anticholinergic effect. This means that it can be taken even by the elderly. The drug does not negatively affect the body with prostatic hypertrophy and angle-closure glaucoma.

But still, the medicine has its own side effects:

Most of the above side effects are due to excessive use of Trittico, that is, an overdose.

Instructions for use

To avoid the side effects of Trittico tablets, the correct dosage must be observed. Usually, it is prescribed by a doctor individually, depending on what disease needs to be cured. The pre-treating physician should conduct a thorough examination of the patient.

Much depends on the blood tests. If a person has a white blood cell deficiency, a large dosage can only worsen his health, as the drug will further reduce the number of white blood cells.

In no case should you take Trittico on your own. Everything is strictly individual. At the beginning of the use of this drug, the dosage is usually increased and then reduced. Thus, many side effects of taking the medicine can be avoided.

Features of taking the drug:

The initial dose for adult patients should not exceed 150 mg per day twice a day.
It is advisable to use the tablets at bedtime, as they may cause severe dizziness.
If necessary, the doctor will recommend increasing the daily dose by another 50 mg. The maximum daily dose for outpatients should not exceed 450 mg, and for inpatients - 600 mg.
Elderly and immunocompromised patients should not take more than 75 mg per day.
In mild forms of depression, you can take a prophylactic agent of no more than 150 mg in three days with two-day breaks.

In case of alcohol dependence, it is recommended to take the remedy half an hour before meals or a couple of hours after meals. The minimum dosage is 100 mg once a day. Gradually, the doctor may increase the amount of the drug. The tablet should be consumed whole without chewing and drinking plenty of water.

The effectiveness of the drug

The main feature of Trittico tablets is that the effect is achieved very quickly - for most people. Fear, irritability, insomnia, chronic headaches cease to disturb the patient. The waking time is significantly reduced, and the quality of sleep actually improves.

An excellent effect is manifested and, if necessary, stabilize the patient's emotional state, improve his mood. The drug is highly effective in the treatment of withdrawal symptoms in people dependent on benzodiazepine. The medicine helps to restore male strength.

In 50% of patients, the positive effect of Trittico tablets is manifested within 2-3 days after regular intake of the drug. But 25% see the effect of using the drug only after two weeks.

In some patients, progress occurs only after four weeks of taking Trittico. In this case, everything is very individual.

Many patients are interested in whether it is possible to combine taking Trittico tablets with alcoholic beverages. No, this is strictly prohibited. Alcohol increases blood pressure, and medication can lower it dramatically. As a result, all this can lead to the development of hypoxia, that is, a lack of oxygen levels in the body. The patient will immediately feel very bad - he will have severe dizziness. The person may even faint.

With a one-time intake of alcoholic beverages and the specified medication, the body will slowly oxidize alcohol, which can lead to serious poisoning. Sometimes there are problems with the central nervous system. The patient becomes lethargic and lifeless. If you do not stop taking alcoholic beverages, the situation can worsen. Respiratory disorders and coma are not excluded.

The danger of the simultaneous use of alcohol and Trittico pills lies in the destructive effect that is on the patient's liver. The drug is excreted from the body through this internal organ.

Drinking alcohol can lead to a sharp deterioration in liver function and its complete intoxication. More serious consequences are also likely - the patient may develop toxic hepatitis in a complex form.

Doctors say for sure that a one-time consumption of Trittico and alcoholic beverages cannot lead to the patient's recovery. All therapeutic treatments will not bring any positive results. The effect of the pills will be stopped by alcohol.

As a result, the patient will have to undergo treatment again. In this case, it is recommended to take the medicine during remission. But the dosage should be reduced after consulting your doctor.

yatrezv.com

Trittico

The antidepressant Trittico has antidepressant, sedative and anxiolytic effects. Its active ingredient does not affect MAO. The drug has a fast action on mental and somatic symptoms of anxiety. Among them: irritability and fear, insomnia and palpitations, sweating and increased urination. The drug is effective in patients with sleep disorders and depression: it increases the depth of sleep and its duration, and also improves the quality of sleep. The drug is prescribed to persons suffering from chronic alcoholism to stabilize their emotional state and reduce the desire for alcohol. Trittico restores libido and potency in patients with depression, as well as in people who do not suffer from it. It does not affect body weight and is addictive.

Features:

During treatment, it is necessary to refrain from using ethanol. Elderly patients suffering from angle-closure glaucoma and enlargement of the prostate gland are allowed to be treated with the drug.

Indications:

Effective for anxiety-depressive states of an endogenous nature. It can be used to treat psychogenic depression, alcoholic depression and benzodiazepine dependence. Applicable in case of anxiety-depressive syndrome associated with dementia or Alzheimer's disease. Also, the drug can be prescribed to persons with libido or potency disorders.

Reception scheme:

Dosage and dosage regimen is individual and depends on the type and severity of the disease. Take the medicine half an hour before meals or two hours after it. The starting dose is 50-100 mg taken in one dose before going to bed. If the dosage has been increased to 150 mg, it should be divided into two doses (the smaller one before lunch, the larger one before bedtime). Children's dosage is up to 2 mg per kilogram, which should be divided into several doses.

Contraindications:

Side effects:

Treatment may be accompanied by drowsiness and headaches, weakness, fatigue and bitterness in the mouth. Active ingredient The active ingredient is trazodone hydrochloride.

Supporting components

Also included are: sucrose and carnauba wax, povidone and magnesium stearate.

What you need to know before taking the antidepressant Trittico: instructions, reviews

Trittico (Trazodone) is an antidepressant that belongs to the triazolopyridine group. It is produced in the form of long-acting biconvex tablets, white, 75 and 150 mg of the active ingredient.

The composition contains the active ingredient trazodone hydrochloride and impurity components: wax, cane sugar, magnesium stearate, povidone.

pharmachologic effect

The functional component of the drug is trazodone, which has an antidepressant effect with a sedative and anxiolytic effect.

The drug differs from other antidepressants in its tricyclic structure and in the absence of monoamine oxidase. The active ingredient trazodone quickly eliminates somatic and mental symptoms, especially effective in sleep disorders.

Also, the drug is able to normalize an excited pathetic state, restores potency and improves mood.

Trazodone shares some similarities with certain types of serotonin receptors. The medication removes the pathogenetic cause of depression (serotonin deficiency), as a result of which it has an antidepressant effect.

When the active substance acts on the body, emotional tension is eliminated, the feeling of panic disappears, and falling asleep is accelerated. The medication eliminates symptoms such as headache, tachycardia, myalgia and signs of aggravated anxiety and anxiety.

As a result of the action of the drug, normal sleep is restored. During the course of the therapeutic course, the stabilization of the emotional state is noted and the craving for alcohol decreases in the presence of withdrawal symptoms.

Addiction to this drug was not recorded. The active ingredient has no anticholinergic activity and therefore has no effect on heart function.

The algorithm of functioning of Trittico lies in the ability to influence the serotonergic system. The active substance selectively blocks the return rejection of serotonin.

The medication provokes an adrenergic blocking effect and reduces the susceptibility of beta-adrenergic receptors. The active ingredients affect the neuronal uptake of dopamine and norepinephrine. The drug is especially effective for sleep disorders in patients who are in a state of apathy. The medication significantly improves mood and general pathetic state.

Pharmacokinetics of the drug

The drug has a high absorption rate from the gastrointestinal tract. Simultaneous intake of the drug with food slows down the absorption time.

The maximum accumulation of the constituents of the drug in the blood plasma is observed 1-2 hours after its internal intake. The ability to commute drug components and plasma proteins is 90-95%. The active ingredient is able to penetrate the granulocytic barriers and can pass into breast milk.

The metabolic process takes place in the liver, followed by the release of the active metabolite of chlorophenylpiperazine. The half-life of the drug is 3-6 hours. A significant amount of anthrols is excreted by the kidneys (75%). Full exit stops 98 hours after drug use. About twenty percent of the drug is excreted in the bile.

Indications and contraindications for use

Trittico is prescribed for the following diseases:

Contraindications to the appointment of the drug:

hypersensitivity to the active ingredient of the drug;
period of pregnancy;
children up to age six;
hepatic or renal impairment;
a history of priapismoma;
the manifestation of symptoms of ventricular premature beats;
arterial hypertension;
the initial period of remission after a heart attack;
the presence of tachycardia.

Instructions for use

Trittico tablets are prescribed for internal use, 30 minutes before a meal, or four hours after a meal.

It is recommended to use the tablets without chewing, as the integrity of the film shell may be violated. The course of treatment should be started with a dose of 50-100 mg at a time. This amount should be consumed within the first three days of the therapeutic course.

Starting from the fourth day, the dose of the drug must be increased to 150 milligrams per day. Further, the amount of the drug should be increased by 50 mg per day, until the required therapeutic dose is established.

In general, the total daily amount of medication should not exceed 150 mg at a time. The drug use regimens differ depending on the age category of patients:

Age 18. The daily dose is calculated in the amount of 1-2 mg per body weight. The set amount is divided into several steps. If necessary, the daily amount of the drug can be gradually increased every three days to a total dose of 6 mg per 1 kg of body weight.
Elderly and malnourished patients. The course of therapy for this category of patients begins with a dose of 100 mg per day. Further, the amount of the drug is increased to a total daily dose of 300 mg.

During pregnancy and during breastfeeding, the drug is not recommended for use. For patients with impaired kidney and liver function, the drug is prescribed with extreme caution. Trittico is also not prescribed in childhood (up to six years). When undergoing a course of treatment with this medication, it is not recommended to consume alcohol.

Overdose and side effects

In case of an overdose of Trittico, such reactions from the nervous system appear: tremors, drowsiness, agitation and headaches. Digestive disorders are also observed, resulting in nausea, bitterness, etc.

Of the side effects, the following reactions appear:

cardiovascular system - decrease in blood pressure, leukopenia, neutropenia, bradycardia, impaired conduction;
digestive system - diarrhea, vomiting, nausea, decreased appetite;
the main and peripheral nervous system - severe fatigue, disorientation, trembling, dizziness, numbness of the limbs and general weakness.

To get rid of all of the above symptoms, you need to carry out symptomatic therapy and remove the remnants of the medication from the body with the help of diuretic drugs.

The active ingredient trazodone can enhance the effects of certain antihypertensive medications. In this case, it is required lower doses of both medicines.

When used synchronously with drugs that suppress the central nervous system, the effect of the latter is significantly augmented.

Antihistamine medicine and medicines with anticholinergic efficacy provoke an increase in the anticholinergic effect of trazadone. When taken in parallel with tricyclic stimulants, an increase in the sedative and anticholinergic effect occurs.

When taken simultaneously with MAO blockers and carbamazepine, the likelihood of undesirable effects increases.

Practical application experience

Reviews of doctors and patients who have undergone treatment with Trittico.

A very effective drug. For depression, I prescribe it in combination with other medications. I observed few side effects during my medical practice.

Subject to all the necessary instructions of the doctor, the therapeutic effect occurs within seven days after the start of the use of the medication.

Galina Alexandrovna, psychotherapist

I rarely prescribe this medication. This is due to the fact that in some cases, too long-term sedation may occur. It all depends on the body's hypersensitivity.

Boris Evgenievich, neurologist

I took half a pill twice a day. My mouth was constantly dry, my breathing was somehow uneven and constantly nauseous. I decided not to take it anymore. The doctor advised me to replace the drug, which I did.

At one time, I also took Trittico for three weeks. The drug helped me a lot, but I was constantly sleepy. I did not observe any other side reactions.

From the reviews it is clear that the medication is effective, the only drawback is the frequent manifestation of side effects. Before using the medicine, you must first consult with your doctor.

Purchase of the drug and its analogues

Trittico is available in the form of tablets, in blisters and cartons, the average price for the drug is 650-700 rubles.

Trittico antidepressant analogs:

Alventa;
Velaxin;
Venlift;
Deprexor;
Medofaxin;
Prefaxine;
Brintellix.

Trittico instructions for use, contraindications, side effects, reviews

Antidepressant. Drug: TRITTICO

Active substance of the drug: trazodone

ATC coding: N06AX05 KFG: Antidepressant Reg. number: P No. 015703/01 Date of registration: 31.05.04

Owner reg. ID: Aziende Chimiche Riunite ANGELINI FRANCESCO A.C.R.A.F. S.p.A. (Italy)

Trittico release form, drug packaging and composition.

1 tab. trazodone hydrochloride

15 pcs. - blisters (2) - cardboard packs. 30 pcs. - blisters (1) - cardboard packs.

Controlled-release tablets, white or white with a yellowish sheen, oval, with two parallel lines on both sides.

1 tab. trazodone hydrochloride

Excipients: sucrose, carnauba wax, povidone (polyvinylpyrrolidone), magnesium stearate.

10 pieces. - blisters (2) - cardboard packs. 10 pieces. - blisters (6) - cardboard packs. 20 pcs. - blisters (1) - cardboard packs.

20 pcs. - blisters (3) - cardboard packs.

The description of the product is based on the officially approved instructions for use.

Pharmacological action of Trittico

Antidepressant. Trazodone, being a triazolopyridine derivative, has a predominantly antidepressant effect, with some sedative and anxiolytic effects. Trazodone has no effect on MAO, which distinguishes it from MAO inhibitors, tricyclic antidepressants.

The mechanism of action of trazodone is associated with the high affinity of the drug for some subtypes of serotonin receptors, with which trazodone enters into antagonistic or agonistic interactions, depending on the subtype, as well as with the specific ability to cause inhibition of serotonin reuptake.

Quickly affects mental (affective tension, irritability, fear, insomnia) and somatic symptoms of anxiety (palpitations, headache, muscle pain, increased urination, sweating, hyperventilation).

Trazodone is effective for sleep disorders in patients with depression, increases the depth and duration of sleep, restores its physiological structure and quality.

Trittico stabilizes the emotional state, improves mood, reduces the pathological craving for alcohol in patients suffering from chronic alcoholism during the period of alcohol withdrawal syndrome, also in remission. With withdrawal symptoms in patients with dependence on benzodiazepine derivatives, trazodone is effective in the treatment of anxiety-depressive states and sleep disorders. During remission, benzodiazepines can be completely replaced with trazodone.

Promotes the restoration of libido and potency, both in patients with depression and in persons without depression.

The drug is not addictive. It has little effect on the neutral uptake of norepinephrine and dopamine.

Does not affect body weight.

Pharmacokinetics of the drug.

Suction

Absorption of the drug from the gastrointestinal tract after oral administration is high. Taking trazodone during or immediately after a meal slows down the rate of absorption, reduces the Cmax of the drug in the blood plasma and increases the Tmax. Cmax in blood plasma is achieved within 0.5-2 hours after oral administration.

Distribution

Plasma protein binding - 89–95%. Penetrates through histohematogenous barriers, as well as into tissues and fluids (bile, saliva, breast milk).

Metabolism

Trazodone is metabolized in the liver, the active metabolite is 1-m-chlorophenylpiperazine.

Withdrawal

T1 / 2 is 3-6 hours, in the second phase - 5-9 hours. Most of the metabolized drug is excreted by the kidneys - about 75%, and is completely completed 98 hours after administration; with bile, about 20% is introduced.

Indications for use:

Anxiety-depressive states of endogenous nature (including involutional depressions);

Psychogenic depression (including reactive and neurotic depression);

Anxiety-depressive states against the background of organic diseases of the central nervous system (dementia, Alzheimer's disease, atherosclerosis of the cerebral vessels);

Depressive states with prolonged pain syndrome;

Alcoholic depression;

Benzodiazepine dependence;

Libido and potency disorders.

Dosage and method of administration of the drug.

The drug is taken orally 30 minutes before meals or 2-4 hours after meals. The prescribed dose of the tablet should be taken whole, without chewing and drinking plenty of water.

Adults are prescribed in an initial dose of 100 mg 1 time / day after meals at bedtime. On the 4th day, you can increase the dose to 150 mg. In the future, in order to achieve the optimal therapeutic effect, the dose is increased by 50 mg / day every 3-4 days until the optimal dose is reached. A daily dose of more than 150 mg should be divided into 2 doses, with the lower dose taken in the afternoon, and the main dose at bedtime.

The maximum daily dose for outpatients is 450 mg.

The maximum daily dose for inpatients is 600 mg.

In the treatment of impotence, in the case of monotherapy with the drug, the recommended daily dose is more than 200 mg, with combined therapy - 50 mg.

In the treatment of benzodiazepine dependence, the recommended treatment regimen is based on a gradual, sometimes over several months, dose reduction of the benzodiazepine. Each time, reducing the dose of benzodiazepine by 1/4 or 1/2 tablet, 50 mg of trazodone is simultaneously added. This ratio is left unchanged for 3 weeks, then a further gradual decrease in the dose of benzodiazepines is started until they are completely canceled. Thereafter, the daily dose of trazodone is reduced by 50 mg every 3 weeks.

For elderly and debilitated patients, the initial dose is up to 100 mg / day in divided doses or 1 time / day before bedtime. The dose can be increased under the supervision of a physician, depending on the effectiveness and tolerability of the drug. Usually, a dose exceeding 300 mg / day is not required.

Children aged 6–18 years: initial daily dose of 1.5–2 mg / kg / day, divided into several doses. If necessary, the dose is gradually increased to 6 mg / kg / day with an interval of 3-4 days.

Side effects of Trittico:

From the side of the central nervous system and peripheral nervous system: increased fatigue, drowsiness, agitation, headache, dizziness, weakness, myalgia, discoordination, paresthesia, disorientation, tremor.

From the side of the cardiovascular system: a decrease in blood pressure, orthostatic hypotension (especially in persons with vasomotor lability) is caused by the adrenolytic effect of the drug, arrhythmia, conduction disturbances, bradycardia, leukopenia and neutropenia (usually insignificant).

On the part of the digestive system: dry and bitter mouth, nausea, vomiting, diarrhea, loss of appetite.

Others: allergic reactions, eye irritation, priapism (patients who experience this side effect should immediately stop taking the drug and consult a doctor).

Contraindications to the drug:

Pregnancy;

Lactation period;

Children under 6 years old;

Hypersensitivity to drug components.

The drug should be prescribed with caution to patients with AV blockade, myocardial infarction (early recovery period), with arterial hypertension (correction of doses of antihypertensive drugs may be required), ventricular arrhythmia, a history of priapism, with renal and / or hepatic insufficiency, patients under the age of 18 years.

Application during pregnancy and lactation.

The drug is contraindicated for use during pregnancy and lactation (breastfeeding).

Special instructions for the use of Trittico.

Since the drug has some adrenolytic activity, bradycardia and a decrease in blood pressure may develop. Therefore, the drug should be prescribed with caution to patients with impaired cardiac conduction, AV block of varying severity, patients with recent myocardial infarction.

When using trazodone, a slight decrease in the number of leukocytes is possible, which does not require specific treatment, except in cases of severe leukopenia. Therefore, during the period of treatment, it is recommended to conduct peripheral blood tests, especially if there is a sore throat when swallowing and the appearance of fever.

The drug does not have an anticholinergic effect, therefore it can be prescribed to elderly patients suffering from prostatic hypertrophy, angle-closure glaucoma, and impaired cognitive functions.

When prolonged and inadequate erections appear, the patient should consult a doctor.

During the period of treatment, the patient should refrain from drinking alcohol.

Use in pediatrics

There have been no relevant studies on the effectiveness of the drug in pediatrics, so the drug should be used with caution in children and adolescents under the age of 18. Doses for children under 6 years of age have not been established.

Influence on the ability to drive vehicles and use mechanisms

Since the drug has anxiolytic and sedative activity, the ability to concentrate and the speed of psychomotor reactions may decrease. During treatment, the patient should avoid engaging in potentially hazardous activities, incl. driving vehicles and controlling mechanisms.

Drug overdose:

Symptoms: nausea, drowsiness, arterial hypotension, increased frequency and severity of side effects.

Treatment: there is no specific antidote for the drug. In cases of overdose, symptomatic treatment is carried out (including gastric lavage, forced diuresis).

Interaction of Trittico with other drugs.

Trazodone can increase the effect of some antihypertensive drugs and usually requires a reduction in their doses.

Simultaneous administration with drugs that depress the central nervous system (including clonidine, methyldopa) enhances the effect of the latter.

Antihistamines and drugs with anticholinergic activity enhance the anticholinergic effect of trazodone.

Conditions of sale in pharmacies.

The drug is available by prescription.

Terms of storage of the drug Trittico.

List B. The drug should be stored out of the reach of children at a temperature not exceeding 25 ° C. The shelf life is 3 years.

How to take Trittico tablets: instructions

The medicine Trittico is a high quality muscle relaxant antidepressant, which includes a substance derived from thiazolopyridine. The calming and sedative effect occurs due to the fact that the drug has a similarity to serotonin receptors, therefore, the reuptake of the so-called happiness hormones is excluded.

Detailed description and effectiveness of the drug Trittico

Trittico medicine is available in the form of tablets, which are white with a yellowish tinge. They are oval in shape. There are two parallel incisors on both sides of the tablet. Each of them contains 75 mg of trazodone hydrochloride. The auxiliary substances are: magnesium stearate, polyvinylpyrrolidone, carnauba wax and sucrose.

Trittico medicine, even with prolonged use, is not addictive. It does not promote weight gain and is neutral to the uptake of dopamine and norepinephrine.

The main feature of the drug Trittico is a quick effect on mental (fear, irritability, emotional tension, insomnia) and somatic manifestations (symptoms) of anxiety (muscle and headaches, sweating, palpitations, frequent urination, hyperventilation). This drug has a positive effect on sleep disorders in those people who are depressed. Trittico reduces waking time. At the same time, the quality of sleep in patients improves.

This drug also perfectly stabilizes the emotional state and improves mood. It is also effective in the treatment of withdrawal symptoms in those patients who are addicted to derivatives such as benzodiazepine and trazodone. In addition, this medicine helps restore male strength. Whether patients suffer from lingering depression or not.

Indications and contraindications, side effects

disorders of potency and libido, including those caused by depressive conditions;
benzodiazepine dependence;
depressive conditions accompanied by high anxiety against the background of diseases of the central nervous system (Alzheimer's disease, dementia, cerebral atherosclerosis);
alcoholism;
psychogenic depression;
violation of the emotional state due to prolonged pain syndrome;
alcoholic depression.

Do not use Trittico in the following cases:

lactation period;
pregnancy;
high sensitivity to the main and / or additional components of the drug.

It is necessary to take this product with special care by persons who drive a vehicle, since a loss of concentration is not excluded.

Trittico is not prescribed for children under 6 years of age. It is prescribed with caution when:

atrioventricular block;
episodes of priapism in history;
ventricular arrhythmias;
myocardial infarction;
postinfarction period;
arterial hypertension;
liver failure;
heart problems;
renal failure.

This drug does not have an anticholinergic effect, so it can be prescribed to elderly patients who have angle-closure glaucoma, prostatic hypertrophy or impaired cognitive functions. This medicine will not affect the course of these diseases in any way.

It should be borne in mind that the drug Trittico has side effects that may occur while taking it. They manifest themselves as follows:

drowsiness;
bitterness in the mouth;
increased fatigue;
orthostatic hypotension;
hypotension;
allergic reactions in various parts of the body;
paresthesia;
headaches, asthenia;
severe dry mouth;
arrhythmia;
dizziness;
increased arousal;
anorexia;
violations of myocardial conduction;
pain;
disorientation;
myalgia;
neutropenia;
nausea;
diarrhea;
tremor;
eye irritation;
bradycardia;
priapism;
leukopenia;
lowering blood pressure;
lack of coordination;
vomiting.

The dosage of the drug is prescribed depending on the patient's condition and his illness. Moreover, it must be selected by the attending physician after a thorough examination of the patient. Blood test results are important. Indeed, if a person has a deficiency of leukocytes, then taking this drug in a large dosage can aggravate the situation, since it helps to reduce their number.

You can not use this medicine at your own discretion, or after reading reviews of other people, which provided recommendations for its use, since this drug provides for a special and individual treatment regimen, where the dosage first gradually increases and then gradually decreases in order to minimize the occurrence of side effects and improve the effectiveness of the drug.

Alcohol and medicine Trittico

With alcoholism, Trittico is quite often prescribed, the instructions of which provide special recommendations for the treatment of such an ailment. After all, it is quite serious and requires increased attention. So, during the treatment of alcoholism, it is necessary to completely abandon alcoholic beverages, since they lead to an increase in blood pressure, and the Trittico drug can sharply reduce it, which can cause hypoxia - a lack of oxygen in the body. The patient may feel worsening of the condition. He may experience dizziness, weakness, and loss of consciousness.

Another danger of combining the intake of Trittico and alcoholic beverages is the slow oxidation of alcohol in the body. As a result, it will accumulate, which can lead to poisoning. In addition, there will be serious problems with the functioning of the central nervous system. A person will experience lethargy, speech will slow down, and orientation in the world will be lost. At the same time, if you do not stop taking alcohol, then breathing will worsen and impairment of consciousness will worsen. All this can lead to irreversible consequences, coma is not excluded.

Another danger of the simultaneous intake of alcohol and Trittico lies in the violation of the liver. This drug is excreted from the body mainly through this organ. Therefore, even a not too large dose of alcoholic beverages can dramatically worsen the condition of the liver and lead to its intoxication. In some cases, more serious consequences are possible. A person may develop severe toxic hepatitis.

It should be said that the use of alcoholic beverages in the treatment of alcoholism or other diseases will not lead to the patient's recovery. All therapy that was carried out using the drug Trittico will come to naught. As a result, the patient will need to restart its passage. At the same time, the manufacturers of the drug recommend taking it during remission in order to get the best effect from the treatment. But here it is already required to reduce the dosage of the drug, the attending physician must select the optimal one.

In case of deterioration of health (the appearance of sore throat, fever, and so on) or the ineffectiveness of taking the Trittico medication, the patient should immediately consult a specialist. He will conduct an examination, prescribe additional tests, and then adjust the therapy regimen.

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Pharmacological functions of the drug trittico

Trazodone is considered a functional substance in the drug, which has an antidepressant effect with a sedative and anxiolytic properties.

The drug differs from other antidepressants in its tricyclic structure and complete absence of monoamine oxidase. The active ingredient is trazodog, it is able to quickly remove somatic and mental symptoms, this drug is especially effective during prolonged insomnia.

Also, the remedy can qualitatively normalize the excited pathetic state of a person, restores potency in men and has a positive effect on the general mood.

Trazodone carries a certain similarity with certain types of serotonin receptors in the body. A medicine is able to eliminate the pathogenetic cause of depression (low serotonin levels), resulting in an antidepressant effect on a person.

When the active component of the drug acts on the human body, the tension of the emotional background goes away, the feeling of panic is eliminated, and a quick process of falling asleep occurs. The drug is able to eliminate symptoms such as headache, myalgia, tachycardia and symptoms of an aggravated level of anxiety and anxiety.

Ultimately, the remedy creates the normalization of the sleep pattern. With the passage of a special therapeutic procedure, you can see the stabilization of the emotional state and a decrease in a special attachment to alcohol with the development of withdrawal symptoms.

Addictive this drug was not noticed by the treating specialists. The active components of the drug do not have anticholinergic activity, which is why it is not able to have absolutely any side effect on the functioning of the heart.

The scheme of functioning of the drug Trittico includes the ability to affect the serotonergic system. The active drug begins to actively block the return rejection of serotonin in the body.

Medicinal product provokes adrenergic blocking effect and eliminates the special susceptibility of beta - adrenoceptors. The active ingredients in the composition of the product affect the neuronal uptake of dopamine and norepinephrine. The drug has a greater effect during sleep disturbances in sick people who are in a state of apathy. The medicine can significantly increase the level of mood and emotional mood, as well as the general pathetic state of the patient's body.

Pharmacological action of the drug

The drug has a high degree of absorption from the gastrointestinal tract. Together with this, the agent in the blood plasma begins to actively affect the body within 1-2 hours after ingestion. The ability to switch proteins included in the plasma product is 90–95 percent. The active component of the agent begins to penetrate the granulocytic barriers in the body and is able to enter breast milk.

Metabolic action actively occurs inside the liver, followed by the release of the active substance of the metabolite of chlorophenylpiperazine. The half-life of the drug will be 3–6 hours. A large number of anthrols begin to be actively excreted by the kidneys (in an amount of 75 percent). The complete release of substances occurs after 98 hours after using the product. More than twenty percent of the healing substances begin to be eliminated from the human body together with bile.

Indications for starting the drug

Trittico is worth starting take for the following diseases:

The presence of impotence.
Apathy of a hypogenic form.
Development of involutional depressions.
Cerebral atherosclerosis.
Apathy during prolonged pain.
Dementia due to old age.
Alcoholic disease.
Certain phobias in the human body.
Libido disorder.
For active prevention of migraine.
Bulimia.
Certain anxiety in the body.
Apathy due to developing Alzheimer's disease.
The development of blues at the psychogenic level.
The presence of anxiety syndromes.
Patient's benzodiazepine dependence.

Special contraindications to use the medicine:

The presence of hypersensitivity to any component in the drug.
Development of tachycardia.
The development of arterial hypertension.
Pregnancy or baby feeding.
The child's age is up to six years.
Hepatic or renal failure.
A history of priapism.
The development of symptoms of gastric extrasystole.
The initial stage of recovery after a heart attack.
Arterial hypertension.

Instructions for using the medicinal product

Trittico tablets should be used thirty minutes before eating inside, or after four hours from the moment of eating.

The tablets should be used without chewing them, as the integrity of the film membrane of the drug may be compromised. The course of drug therapy should be started with a dosage of 50-100 mg at a time. This dosage of the drug should be observed throughout all three days of treatment with the drug. Starting from the fourth day, the dosage of the drug should be increased to 150 mg per day. After the number of the drug taken, it is worth increasing over time by 50 mg per day, until the necessary medical norm of the drug is established.

Overall, the overall daily number of medication should not be more than 150 mg at a time. The drug use regimens are based on the age category of the patient.

Age up to 18 years. The daily dose of the drug should be calculated at 1–2 mg per human body weight. The prescribed amount of funds should be divided into several doses of the drug per day. If necessary, the daily intake of the medication can be increased over time. Every three days it is worth increasing the remedy by 6 mg per kilogram of the total dose of the drug.
Elderly as well as malnourished patients. The course of treatment with a drug for this group of patients should begin with a dosage of 100 mg per day. Further, the number of funds should be increased over time to the overall optimal rate of 300 mg per day.

In the process of bearing the fruits and while feeding the baby with mother's milk, the product should not be used at all. Patients with impaired kidney and liver function should be prescribed with even greater caution. Trittico should also not be started at a too young age (under six years of age). At the end of the course of treatment, the use of alcohol is strictly prohibited.

Side effects of Trittico medicine and special contraindications

During an overdose with Trittico, reactions from the human nervous system such as tremors, agitation, headaches and drowsiness begin to occur. You can also notice special disturbances in the human digestive system, due to the development of nausea, bitterness and others.

Of the side signs, one can note:

The cardiovascular system - decrease in blood pressure, neutropenia, bradycardia, leukopenia, conduction disturbance.
Digestive system: decreased appetite, nausea, vomiting, and diarrhea.

The trunk, as well as the peripheral nervous system of a person - an increased level of fatigue, trembling, dizziness, impaired coordination of a person, the process of numbness in the limbs and a high indicator of weakness of the whole organism.

In order to get rid of this symptomatology, it is worth carrying out therapy for determining the incidence of a person, as well as removing the remnants of the drug from the patient's body with the help of diuretic drugs.

Drug interaction of funds

The active ingredient trazodone is capable of acting on antihypertensive drugs by enhancing their effect on the body. In this case, it is worth lowering the dosage of all medications.

During the combined use of medicinal agents that have a cholinolytic feature, they provoke the development of an anticholinergic effect in trazadone. During the parallel use of the agent with tricyclic simulants, an increase in the sedative and anticholinergic effect begins.

During the joint use of the drug with MAO blockers and Carbamazepine, there is an increase in the possibility of developing undesirable symptoms and complications.

The use of the drug trittico

The drug is completely contraindicated in pregnancy and breastfeeding.

Application by children.

The medicine is prohibited for use by children under the age of 6 years. With extreme caution, use the remedy for adolescents under the age of 18 years.

The use of the product by the elderly.

For the elderly, as well as severely weakened people, the initial dosage of the drug is up to 100 mg per day in a fractional proportion, or once a day before bedtime. The dosage of the drug can be increased on the advice of the attending physician, depending on the effectiveness and tolerability of this drug individually for each person. Most often, a dose is used per day that does not exceed the 300 mg mark.

Indications for the use of trittico

Since the treating agent has a special adrenolytic activity, bradycardia or a decrease in blood pressure may develop. It is for this reason that it is worthwhile to prescribe a remedy with extreme caution to patients who have certain disorders in cardiac conduction, AV blockade of varying severity, to patients with a recent myocarditis infarction.

While taking Trittico, there may be a slight decrease in the number of leukocytes in the blood, which does not require special treatment, except in cases of special severity of leukopenia. That is why the time of treatment with the drug should be differentiated during the study of peripheral blood, especially if the throat hurts during swallowing or there is a constant fever.

The drug does not carry an anticholinergic effect, therefore it can be used by patients who suffer from prostate hypertension, angle-closure glaucoma, as well as a special deformation in cognitive functions.

The drug must be used according to a specific prescription from a treating specialist.

With the development of long and inadequate erections in the human body, the patient should immediately go to the attending specialist.

During the course of treatment, you must limit yourself to the use of alcoholic beverages.

Influence on driving vehicles and control of various types of mechanisms

Since the drug contains anxiolytic and sedative functions, it is possible to develop a decrease in the ability to high-quality concentration of attention, as well as the speed of psychomotor reactions inside the patient's body. During the course of treatment with the drug, the patient must protect himself from potential hazardous activities in everyday life, this should also include driving a car, as well as controlling any equipment.

Instructions for using the tool

The drug should be taken orally half an hour before eating or 2–4 hours after eating. The dosage prescribed by a specialist should be used in full, without chewing or drinking with a lot of water.

Adults are usually prescribed an initial dosage of 100 mg once daily after meals at bedtime. On the fourth day of the course of the drug, the dosage should be increased to 150 grams. In the future, in order to achieve the optimal level of therapeutic effect, the dose should be increased by 50 mg per day every 3-4 days until the required level of drug use is reached.

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Antidepressant Trittico

Trittico tablets have thymoleptic, muscle relaxant, mild sedative and anxiolytic effects. Due to the peculiarities of the composition of the basic substance, which is similar to the structure of serotonin receptors, the main pharmacological action is associated with the suppression of serotonin reuptake. The drug has no effect on the ability of neurons to seize dopamine and norepinephrine.

In addition to the mental manifestations of anxiety states - increased irritability, fears, sleep disturbances - the use of the drug Trittico, according to the instructions, removes the somatic signs of developing depression, such as tachycardia, increased sweating, hyperventilation, and frequent urge to urinate. In patients with depression, during the course of treatment with this antidepressant, normalization of the physiological structure of sleep, an increase in its depth and duration is observed.

Trittico medicine helps to restore libido and improve the quality of potency. When taking the drug, alcohol addicts have a decrease in craving for drinks containing ethanol. During the treatment of alcoholism, the medication effectively relieves withdrawal symptoms and the accompanying depressive disorder. According to doctors' reviews, trazodone can replace the dose of benzodiazepines during the recovery period of patients, so drugs containing them can be completely excluded from therapy.

Composition and form of release

The drug Trittico is available in oval-shaped tablets of white or white-yellow color, which may contain 75 or 150 mg of the main active ingredient - trazodone hydrochloride. Packing forms for 75 mg tablets - 15 or 30 pieces, for a dosage of 150 mg - 10 or 20 pieces. The complete composition of the antidepressant is presented below:

Pharmacodynamics and pharmacokinetics

The drug is produced on the basis of a triazolopyridine derivative. It has an antidepressant effect, has a mild sedative effect, relieves anxiety symptoms, fights sleep disorders, and evens out the general emotional background of a patient in a state of depression. Trazodone hydrochloride has no effect on the breakdown of monoamine oxidase in comparison with the active substances of tricyclic antidepressants.

According to the instructions for use, trazodone is absorbed by the gastrointestinal tract (mainly in the intestines), the maximum concentration of the substance occurs 1.5-2 hours after ingestion. If the drug is taken during or after meals, the period of absorption and reaching the maximum plasma concentration is increased. The binding of trazodone hydrochloride to blood plasma proteins reaches 89-95%, it easily penetrates into all fluids - saliva, breast milk, bile.

Indications for use

The properties described in the instructions of the drug Trittico determine its appointment in various forms of depressive conditions, in the complex treatment of alcoholism, therapy of disorders of the nervous system. Indications for the use of an antidepressant are:

somatogenic, psychotic, neurotic or endogenous depression;
decreased libido and sexual activity;
insomnia and other sleep disorders;
disorders of appetite and eating behavior (bulimia, anorexia);
increased fatigue, chronic fatigue syndrome;
various phobias, obsessive states;
dependence on benzodiazepine drugs.

How to take Trittico

The instruction for the Trittico preparation contains general recommendations for its use. The treatment regimen is developed by the attending physician, depending on the specific diagnosis, the severity of the condition and the individual characteristics of the patient's body. The remedy is taken half an hour before or two hours after a meal. The tablets are not chewed, washed down with water. The maximum daily dose of trazodone in stationary conditions is 600 mg / day, in outpatient conditions - 45 mg / day.

Initial doses of Trittico, depending on the diagnosis, vary in the range of 50-100 mg once a day (before bedtime). Every three days, the dosage is gradually increased (by 50 mg) until an antidepressant effect is achieved (not exceeding the maximum daily dose). Reception is divided into two approaches, the main part of the drug is taken in the evening. Features of admission, depending on the condition and diagnosis, are as follows:

old age - the daily dosage is gradually increased from 100 to 300 mg;
sexual desire disorder - daily dose of 50 mg;
children's age (from 6 to 18 years old) - 1.5 mg per kilogram of weight.

special instructions

Instructions for use Trittico recommends taking the drug with caution in case of interruptions in pressure (with arterial hypertension or hypotension). Due to the adrenolytic activity of trazodone, the manifestation of bradycardia is possible, therefore, if a patient has a history of myocardial infarction, it is necessary to carefully monitor pressure drops during therapy.

According to doctors' observations, the sedative effect caused by taking Trittico can disrupt the speed of psychomotor reactions and reduce attention. For the period of treatment, it is recommended to abandon activities requiring high precision. Children and adolescents from 6 to 18 years old, persons with impaired liver and kidney function, the drug can be prescribed in acute conditions.

During pregnancy

According to the instructions, the use of Trittico is contraindicated during pregnancy and breastfeeding. There is no data on the ability of trazodone hydrochloride to penetrate through the placental barrier; therefore, an objective assessment of the effect of taking the drug on fetal development and the overall course of pregnancy is impossible. The substance penetrates into breast milk, therefore, if there is an urgent need to treat the mother with the use of this antidepressant, the process of feeding the baby should be suspended.

In childhood

The appointment of Trittico to children is made with caution and only if there is an urgent need. At the age of 6 years, the drug is contraindicated. The daily dosage, scheme and duration of treatment are prescribed by the doctor. In the instructions for use, it is not recommended to exceed the daily dose calculated based on the proportion of 1.5 mg of trazodone for each kilogram of the child's weight. Treatment is carried out under the regular supervision of specialists.

Drug interactions

Trazodone actively interacts with substances of other antidepressants and potent drugs, therefore, the instructions for use describe the following features of the interaction of Trittico:

enhances the anticholinergic and sedative effect of drugs such as Haloperidol, Phenothiazine, Pimozide, Thioxanthen, Loksapin, tricyclic antidepressants;
increases the effect of drugs that lower blood pressure;
co-administration with monoamine oxidase inhibitors increases the risk of side effects and the concentration of Digoxin and Phenytoin in blood plasma;
co-administration with carbamazepine will reduce the plasma concentration of trazodone.

The use of alcohol during the course of treatment with Trittico is not recommended in the instructions for use. Taking the drug increases the load on the liver and kidneys, the cardiovascular system, therefore, the parallel use of alcohol increases the risk of side effects such as arrhythmia and other reactions from the heart. Particularly dangerous is the joint intake of Trittico with alcohol for people with a history of myocardial infarction.

Trittico side effects

During the course of treatment with Trittico, according to the instructions for use, side effects from the central nervous and cardiovascular systems are possible (dizziness and headaches, myalgia, impaired coordination of movements, drowsiness; drops in blood pressure, fainting). In some cases, negative consequences are manifested in the form of nausea, visual impairment, hematopoiesis functions (formation of leukocytes) - leukopenia, neutropenia.

Overdose

The main evidence of drug overdose, according to reviews, are nausea, a sharp drop in blood pressure, dizziness and fainting. In the event of such reactions, it is necessary to stop taking the drug and undergo a course of rehabilitation therapy. According to the instructions for use, there is no specific antidote for trazodone, therefore, treatment is carried out in accordance with the symptoms.

Contraindications

Trittico's instructions for use describe a number of conditions in which taking the drug is strictly not recommended. In addition to children under 6 years of age and periods of pregnancy and lactation, the main contraindications include:

arterial hypertension;
chronic tachycardia;
early recovery period after myocardial infarction;
individual intolerance to the components of the drug.

Terms of sale and storage

Trittico is a prescription drug sold in pharmacies. Store the drug, according to the instructions for use, in a dry, dark place out of the reach of children. The shelf life is three years from the date printed on the package.

Analogs

Trazodone hydrochloride antidepressants are not available, except for Trittico. According to the mechanism of action and relation to one pharmacological group, the following drugs are referred to as analogues of this drug:

Azafen;
Befol;
Valdoxan;
Deprim;
Inkazan;
Kraxil;
Lerivon;
Simbalta.

Trittico price

You can buy the drug at the pharmacy or on the appropriate Internet resource. The price range for the drug Trittico, which varies depending on the form of production and packaging of the drug, is presented in the table below:

Video

Trazodone inhibits the neuronal reuptake of serotonin, is an antagonist of serotonin 5-HT 2A / 2C receptors and a blocker of α 1 -adrenergic receptors and has an antidepressant effect.

Pharmacokinetics

Suction

Absorption of trazodone from the gastrointestinal tract after oral administration is high. Taking trazodone during or immediately after a meal slows down the rate of absorption, reduces the C max of the drug in the blood plasma and increases the time to reach the maximum concentration (TC max). C max in blood plasma is achieved within 0.5-2 hours after oral administration.

Distribution

Trazodone crosses the blood-tissue barriers into tissues and fluids (bile, saliva, breast milk).

Plasma protein binding - 89-95%.

Metabolism

Trazodone is metabolized in the liver, the active metabolite is 1-m-chlorophenylpiperazine.

In vitro studies on human microsomes have shown that trazodone is mainly metabolized by the cytochrome P450 isoenzyme (CYP3A4).

Withdrawal

T 1/2 is 3-6 hours, in the second phase - 5-9 hours. Excretion of most of the metabolites of trazodone is carried out by the kidneys in the urine - about 75%, and is completely completed 98 hours after administration; about 20% is excreted in the bile.

Release form

Sustained-release tablets, white or white with a yellowish tinge, oval, biconvex, with two parallel lines on both sides.

Excipients: sucrose - 84 mg, carnauba wax - 24 mg, povidone - 24 mg, magnesium stearate - 6 mg.

10 pieces. - blisters (2) - cardboard packs.
10 pieces. - blisters (6) - cardboard packs.

Dosage

The tablets should be taken orally 30 minutes before meals or 2-4 hours after meals. The tablets should be taken whole without chewing and drinking plenty of water.

Initial dose of the drug: 100 mg, taken once before bedtime after meals. On the 4th day, you can increase the dose to 150 mg. Further dose increases in order to achieve an optimal therapeutic effect should be carried out at 50 mg / day every 3-4 days until the optimal dose is reached.

A daily dose of more than 150 mg should be divided into 2 doses, with the lower dose taken in the afternoon and the main dose at bedtime.

The maximum daily dose for outpatients is 450 mg.

The maximum daily dose for inpatients is 600 mg.

For elderly and debilitated patients, the initial dose is up to 100 mg / day in divided doses or once at bedtime. The dose can be increased under the supervision of a physician, depending on the effectiveness and tolerability of the drug. Usually, a dose exceeding 300 mg / day is not required.

Overdose

Symptoms: drowsiness, dizziness, nausea, vomiting. In more severe cases - coma, tachycardia, arterial hypotension, hyponatremia, convulsions, respiratory failure, impaired cardiovascular function (prolongation of the QT interval, bradycardia). After an overdose, symptoms may appear for 24 hours or more.

Treatment: there is no specific antidote for trazodone. In cases of overdose, it is necessary to wash the stomach and prescribe activated charcoal within 1 hour after taking the drug. Symptomatic and supportive treatment is performed.

Interaction

Trazodone can increase the effect of some antihypertensive drugs, which may require a reduction in their doses.

Simultaneous use with drugs that depress the central nervous system (including clonidine, methyldopa) enhances the effect of the latter.

Blockers of histamine H 1 -receptors and drugs with anticholinergic activity enhance the anticholinergic effect of trazodone.

Trazodone enhances and lengthens the sedative and anticholinergic effects of tricyclic antidepressants, haloperidol, loxapine, maprotiline, phenothiazine, pimozide and thioxanthene.

With the simultaneous use of tricyclic antidepressants and trazodone, cardiovascular side effects may occur.

MAO inhibitors increase the risk of side effects from trazodone.

When used together, it increases the concentration of digoxin and phenytoin in blood plasma.

In vitro studies of drug metabolism indicate the possibility of pharmacological interaction of trazodone with inhibitors of the isoenzyme CYP3A4, such as ketoconazole, ritonavir, indinavir, fluoxetine. The use of CYP3A4 inhibitors can lead to a significant increase in plasma trazodone concentration, thereby increasing the likelihood of adverse events. Therefore, in the case of simultaneous use with potent CYP3A4 inhibitors, the dose of trazodone should be reduced.

After taking trazodone in combination with carbamazepine, the plasma concentration of trazodone decreases. Therefore, patients taking trazadone and carbamazepine at the same time should be closely monitored.

Side effects

Trittico can cause side effects, although not everybody gets them.

From the hematopoietic system: agranulocytosis, thrombocytopenia, eosinophilia, leukopenia, anemia.

From the immune system: allergic reactions.

From the endocrine system: syndrome of inappropriate secretion of ADH.

Mental disorders: suicidal thoughts or suicidal behavior, confusion, mania, phobias, emotional instability, delirium, hallucinations.

From the nervous system: epileptic seizures, dizziness, headache, insomnia or drowsiness, amnesia, tremors, convulsions, paresthesia, impaired taste.

From the side of the cardiovascular system: palpitations, tachycardia, bradycardia, ventricular extrasystoles, ventricular paroxysmal tachycardia, prolongation of the QT interval, increased blood pressure, lowering blood pressure, fainting.

From the digestive system: dry mouth, nausea, vomiting, dyspepsia, abdominal pain, increased salivation, paralytic intestinal obstruction.

From the skin and subcutaneous tissues: itching, erythematous rash, sweating.

From the musculoskeletal system: myalgia, arthralgia.

From the urinary system: urination disorder.

On the part of the genitals and mammary gland: priapism (patients who experience this side effect should immediately stop taking the drug and consult a doctor).

Others: increased fatigue, weakness, fever, flu-like syndrome.

Indications

depression with or without anxiety.

Contraindications

alcohol intoxication and intoxication with sleeping pills;
pregnancy;
lactation period;
children and adolescents under 18 years of age (the safety of trazodone for children has not been established);
deficiency of sucrase / isomaltase, fructose intolerance, glucose-galactose malabsorption syndrome (since the drug contains sucrose);
hypersensitivity to drug components.

The drug should be prescribed with caution in patients with AV blockade, myocardial infarction (early recovery period), arterial hypertension (dose adjustment of antihypertensive drugs may be required), ventricular arrhythmia, a history of priapism, renal and / or hepatic insufficiency.

Application features

Application during pregnancy and lactation

The drug is contraindicated for use during pregnancy and lactation (breastfeeding).

Application for violations of liver function

The drug should be prescribed with caution to patients with hepatic insufficiency.

Application for impaired renal function

The drug should be prescribed with caution in patients with renal insufficiency.

Application in children

The use of the drug in children and adolescents under 18 years of age is contraindicated (the safety of trazodone for children has not been established).

Use in elderly patients

special instructions

With depressive conditions, the risk of manifestations of suicidal thoughts, self-harm or suicide is increased. The risk may last until significant remission occurs. Since improvement may not occur within the first few weeks of treatment or more, patients should be closely monitored until such improvement occurs. According to general clinical experience, the risk of suicide may increase in the early stages of recovery. It is known that patients with a history of suicidal events, or patients who exhibit a significant degree of suicidal ideation even before starting treatment, have a higher risk of suicidal ideation or attempted suicide, and should be closely monitored during treatment. The results of a meta-analysis of placebo-controlled clinical trials of antidepressants, which are used in adults with mental disorders, showed an increased risk of suicidal behavior in patients under the age of 24 years while taking antidepressants compared with placebo. Careful observation of patients, especially those at high risk, should accompany drug therapy, especially in the early stages and after dose changes. Patients (and their carers) should be warned to monitor for any clinical deterioration, suicidal behavior or suicidal thoughts, unusual changes in behavior, and immediately seek professional advice if such symptoms appear.

Since the drug has some adrenergic blocking activity, bradycardia and a decrease in blood pressure may develop. Therefore, caution should be exercised when prescribing the drug to patients with a tendency to lengthen the QT interval, AV block of varying severity, and patients with recent myocardial infarction.

With trazodone therapy in patients with bipolar disorder, depressive attacks can range from manic-depressive to manic psychosis. In these cases, it is necessary to interrupt the treatment.

For epilepsy, trazodone should be used with caution, in particular avoiding sudden increases or decreases in dose.

With the simultaneous use of trazodone with drugs that have serotonergic activity (tricyclic antidepressants, selective serotonin reuptake inhibitors, norepinephrine and serotonin reuptake inhibitors and MAO inhibitors), and antipsychotics, serotonin syndrome may occur.

With the simultaneous use of trazodone with drugs containing St. John's wort, side effects may be more frequent.

With the use of trazodone, agranulocytosis may develop, therefore, it is recommended to conduct peripheral blood tests, especially in the presence of sore throat when swallowing and the appearance of fever.

Trazodone is effective for sleep disorders in patients with depression, increases the depth and duration of sleep, restores its physiological structure and quality.

The use of the drug does not affect body weight.

The drug is not addictive.

Influence on the ability to drive vehicles and use mechanisms

During the period of use of the drug, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions.

Diseases of the nervous system are common these days. They are accompanied by depression, stress, insomnia, and other unpleasant symptoms. To restore the functioning of the nervous system, there are many drugs, including "Trittico". Patient reviews note that the medicine is effective, normalizes sleep, and soothes.

Composition of the preparation

The drug "Trittico" (reviews of patients pay attention to its seriousness and do not advise taking the drug without consulting a doctor) is produced in the form of tablets, which are packed in a blister of 10 pieces. The package may contain two or six blisters, as well as detailed instructions for the use of the medication.

One pill contains about 150 mg of trazodone hydrochloride. The auxiliary components of the drug include carnauba wax, sucrose, magnesium stearate and povidone.

Pharmacology

The drug "Trittico" belongs to the group of long-acting antidepressants (patient reviews indicate side effects that can develop with prolonged use of pills). The drug is a triazolopyridine derivative. It is characterized by anxiolytic, antidepressant and sedative properties.

The tablets relieve the symptoms of anxiety, which has both somatic and psychological origins. First of all, it is a feeling of fear, irritability, nervousness, pain in muscles and head, sweating, insomnia and other symptoms. The medication normalizes the emotional state. Reduces craving for bad and addictive habits such as alcohol.

"Trittico" can be used in patients with withdrawal symptoms and benzodiazepine dependence. The remedy removes the state of anxiety and depression. Improves sleep quality. Tablets have a positive effect on libido, potency. The drug does not develop habituation and does not affect weight gain.

Indications and contraindications

The main indications for the use of the drug "Trittico" (patient reviews believe that the drug relieves hangover syndromes) are depressive and anxious states of various genesis. Doctors recommend this remedy for benzodiazepine addiction, alcohol syndrome, libido disorder, and impotence.

Despite the pronounced effectiveness, the drug is not taken in case of hypersensitivity to this drug and the substances that make up it. It is forbidden to drink these pills for women during pregnancy and while breastfeeding. You can not drink the medication if there is an intoxication of the body. Do not prescribe pills to children under the age of six. Contraindication to taking the medication is a lack of sucrase / isomaltase. Do not drink pills with fructose intolerance, as well as with a diagnosis such as glucose-galactose malabsorption.

Tablets "Trittico": instructions for use

Reviews indicate the need to study the instructions for the drug, since it can cause negative phenomena if used improperly. According to the instructions, start treatment with a daily dosage of 100 mg. From 1 to 3 days, the drug is taken once, at night. From the fourth day, if necessary, the dose is increased to 150 mg. In order to obtain the desired therapeutic effect, the dosage is increased gradually, once every 3-4 days. A daily intake of more than 150 mg is divided into two doses. A smaller dose is drunk at lunchtime, and the main amount of the medication is taken before going to bed.

If the patient is being treated on an outpatient basis, then the daily dosage should not exceed 450 mg (3 tablets), for patients in the hospital, the maximum dose is 600 mg (4 tablets).

The drug is given to children from 6 to 18 years old. Here, the daily dosage is calculated based on 1.5-2 mg / kg of the child's weight. The daily volume is divided into 2-3 doses. To achieve a therapeutic effect, the dose may be increased to 6 mg / kg. Increase the dose gradually, once every 3-4 days.

Older persons start treatment with 100 mg. If the patient tolerates the drug well, then the daily rate is increased to 300 mg / day. To restore libido, the daily dose is 50 mg. With impotence, the dosage can be up to 200 mg or more, and in complex therapy - 50 mg.

Benzodiazepine dependence is treated according to a special regimen. First, reduce benzodiazepines by ¼ or ½ tablet. At the same time, the drug "Trittico" is added. Dose change is carried out once every three weeks, until the complete abolition of benzodiazepines. When only Trittico tablets remain in the treatment, they begin to reduce the dosage of this drug once every three weeks. The tablets are drunk whole. They cannot be chewed. The drug is taken half an hour before meals or 2-4 times after meals.

Overdose and side effects

The medicine "Trittico" (reviews of doctors and patients note that the drug has a strong hypnotic effect) requires strict adherence to the dosage, otherwise an overdose may occur. As a rule, this is a gag reflex, drowsiness, nausea, dizziness. In especially severe cases, tachycardia, cramps in the limbs, hypotension, disturbance in the work of the respiratory and cardiac apparatus, hyponatremia may appear. All of the above symptoms appear in a person within 24 hours.

The drug "Trittico" can also cause negative effects, such as agranulocytosis, leukopenia, anemia, eosinophilia and thrombocytopenia. The patients complained of allergic reactions. Some developed mental disorders, which manifested themselves in the form of phobias, confusion of thoughts, fear, suicidal behavior, hallucinations.

When treated with this medication, especially at high dosages, epileptic seizures, headache and dizziness occurred. Drowsiness developed. Tremors, amnesia were observed, and taste preferences changed frequently. During therapy, people were worried about tachycardia, increased heart rate, bradycardia, decrease and increase in blood pressure. There were ventricular extrasystoles. There was a prolongation of the QT interval. In some cases, patients lost consciousness.

Other side effects included nausea, abdominal pain, vomiting, diarrhea, dry mouth, excessive salivation. There was a rash on the skin, itching, sweating worried.

special instructions

Patients with suicidal thoughts should be monitored by a physician. This condition can last until severe remission and is most often manifested at the initial stage of recovery. Persons under the age of 24 are especially susceptible to suicide.

The adrenergic blocking property of the drug can cause a sharp decrease or increase in blood pressure. Because of this, people with prolonged QT interval should be especially careful when treating Trittico. This applies to patients who have had a heart attack and suffer from atrioventricular block.

If the patient has a manic-depressive psychosis during treatment, then therapy should be discontinued. People with epilepsy should take the drug carefully, without making a sudden dose adjustment.

The tablets are good for insomnia caused by depression. In this case, they lengthen sleep, make it deeper, and restore it. The drug has no effect on the patient's weight and is not addictive.

"Trittico": analogues

Trittico: instructions for use and reviews

Trittico is an antidepressant.

Release form and composition

Dosage form Trittico - tablets of prolonged action (controlled release tablets): white with a yellow tint or white, biconvex, oval, a dividing line is applied on both sides (in blisters: 150 mg - 10 pcs., In a cardboard box 2 or 6 blisters; 20 pcs., In a cardboard box 1 or 3 blisters; 75 mg each - 15 pcs., In a cardboard box 2 blisters; 30 pcs., In a cardboard box 1 blister).

1 tablet contains:

active substance: trazodone hydrochloride - 75 mg or 150 mg;
auxiliary components: sucrose, povidone (polyvinylpyrrolidone), carnauba wax, magnesium stearate.

Pharmacological properties

Pharmacodynamics

Trittico is a drug with an antidepressant effect and a slight anxiolytic and sedative effect. Its active ingredient, trazodone, is a triazolopyridine derivative. Unlike MAO (monoamine oxidase) inhibitors and tricyclic antidepressants, it has no effect on MAO.

The mechanism of action of the drug is due to the specific ability of trazodone to cause inhibition of serotonin reuptake and its high affinity for some subtypes of serotonin receptors. Depending on their subtype, the interaction of trazodone is antagonistic or agonistic.

Trittico has a rapid effect on the somatic and mental symptoms of anxiety. Somatic symptoms of anxiety include sweating, hyperventilation, headache, muscle aches, palpitations, and frequent urination. Mental symptoms - fear, affective tension, insomnia, irritability.

In patients with depression, the drug is effective for sleep disorders, increases the duration and depth of sleep, and helps to restore its quality.

Trittico's action stabilizes the patient's emotional state, improves mood. In patients with chronic alcoholism, during the period of alcohol withdrawal syndrome and remission, it causes a decrease in the pathological craving for alcohol. In case of withdrawal symptoms after the withdrawal of benzodiazepine derivatives, the use of trazodone is effective for the treatment of sleep disorders and anxiety-depressive conditions. During the period of remission, benzodiazepines can be completely replaced with Trittico.

Trittico has little effect on the neutral uptake of dopamine and norepinephrine, is not addictive and does not affect body weight.

Trazodone helps restore potency and libido, including in patients with depression.

Pharmacokinetics

After taking Trittico inside, trazodone is well absorbed from the gastrointestinal tract (GIT). The time to reach the maximum plasma concentration (TC max) of trazodone is 1.5–2 hours. Simultaneous food intake reduces the rate of absorption and increases TC max.

Trazodone is absorbed into tissues and fluids, including breast milk, bile, and saliva.

Plasma proteins bind 89–95% of the dose taken.

It is metabolized in the liver with the formation of an active metabolite - 1-m-chlorophenylpiperazine. According to research results, it is believed that metabolism mainly occurs with the participation of the isoenzyme of cytochrome P 450 (isoenzyme CYP3A4).

The half-life is 3-6 hours, in the second phase - 5-9 hours.

It is excreted to a greater extent in the form of metabolites, through the kidneys - about 75%, with bile - about 20%. Completely excreted 98 hours after ingestion.

Indications for use

depressive conditions due to prolonged pain syndrome;
psychogenic depression, including reactive and neurotic;
involutional depression and other anxiety-depressive states of endogenous etiology;
alcoholic depression;
anxiety-depressive states arising from organic disorders of the central nervous system (CNS) - atherosclerosis of the cerebral vessels, dementia, Alzheimer's disease;
benzodiazepine dependence;
disorder of libido or potency, including against the background of depressive conditions.

Contraindications

isomaltase (sucrase) deficiency, glucose-galactose malabsorption syndrome, fructose intolerance;
intoxication due to alcoholism and hypnotics;
period of pregnancy;
breast-feeding;
age up to 6 years;
hypersensitivity to the components of the drug.

According to the instructions, Trittico should be prescribed with caution in arterial hypertension, atrioventricular block (AV block), ventricular arrhythmia, myocardial infarction (early recovery period), hepatic and / or renal failure, a history of priapism, under the age of 18 years.

Instructions for use of Trittico: method and dosage

Trittico tablets are taken orally, swallowed whole, washed down with a sufficient amount of water, 0.5 hours before or 2-4 hours after a meal.

depression with and without anxiety: the initial dose is 100 mg once at bedtime. After three days of therapy, the dose can be increased to 150 mg. Further, until the optimal clinical effect is achieved, the dose should be increased by 50 mg every 3-4 days. If the daily dose exceeds 150 mg, then it should be divided into 2 doses: after lunch, a smaller dose is taken, before bedtime, the main dose. Maximum daily dose: for outpatients - 450 mg, for inpatients - 600 mg;
impotence treatment: monotherapy - more than 200 mg per day, in combination therapy - 50 mg per day;
treatment of libido disorders: 50 mg per day;
benzodiazepine dependence: according to the scheme, which provides for a simultaneous decrease in the dose of benzodiazepine by 1/4 or 1/2 tablet and an increase in the dose of trazodone by 50 mg, is taken within 21 days. Then continue to gradually reduce the dose of benzodiazepines, each time increasing the dose of trazodone. After the complete withdrawal of benzodiazepine, the daily dose of trazodone is reduced by 50 mg with an interval of 21 days.

The initial dose of Trittico for debilitated and elderly patients should be no more than 100 mg per day. It is selected individually and administered once before bedtime or divided into two doses. The dose increase should be carried out under the supervision of a physician, taking into account the effectiveness and tolerability of the drug. For this category of patients, it is not recommended to exceed the maximum daily dose of 300 mg.

For children aged 6 to 18 years, the dose is determined taking into account the weight of the child at the rate of 1.5–2 mg per 1 kg of body weight per day and divided into several doses. To achieve the desired therapeutic effect, the initial dose of Trittico can be gradually increased, observing an interval of 3-4 days. The maximum daily dose for children should not exceed 6 mg per 1 kg of body weight.

Side effects

mental disorders: emotional instability, mania, confusion, hallucinations, phobias, delirium, suicidal thoughts, suicidal behavior;
from the blood and lymphatic system: anemia, agranulocytosis, leukopenia, thrombocytopenia, eosinophilia;
from the nervous system: impaired taste, insomnia or drowsiness, headache, dizziness, epileptic seizures, amnesia, tremors, paresthesia, convulsions;
from the endocrine system: SNS ADH (syndrome of inappropriate antidiuretic hormone secretion);
from the cardiovascular system: lowering blood pressure (BP), increased blood pressure, palpitations, tachycardia, ventricular extrasystoles, bradycardia, prolongation of the QT interval, ventricular paroxysmal tachycardia, loss of consciousness;
from the immune system: allergic reactions;
from the gastrointestinal tract: dry mouth, nausea, vomiting, diarrhea, increased salivation, abdominal pain, dyspepsia, paralytic intestinal obstruction;
from the reproductive system: priapism;
from the musculoskeletal and connective tissue: arthralgia, myalgia;
from the urinary system: violation of urination;
dermatological reactions: sweating, itching, erythematous rash;
others: fever, weakness, flu-like syndrome, fatigue.

Overdose

Symptoms: nausea, vomiting, drowsiness, dizziness, respiratory failure, cardiovascular function (including prolongation of the QT interval, bradycardia, tachycardia), hypotension, convulsions, hyponatremia, coma. Symptoms may appear within 24 hours or more after an overdose.

Treatment: there is no specific antidote. Immediately (preferably within the first hour) after taking an ultra-high dose of Trittico, it is necessary to wash the stomach and take activated charcoal. Further, symptomatic and supportive therapy is prescribed.

special instructions

During depression, the risk of suicidal thoughts or behavior increases, including while taking antidepressants, especially before the age of 24. Therefore, before the onset of pronounced remission, patients need careful monitoring. If unusual changes in behavior appear, you should immediately seek the advice of your doctor.

When prescribing Trittico to patients with impaired cardiac conduction, AV blockade or after a recent myocardial infarction, the adrenolytic activity of trazodone and the risk of developing bradycardia and lowering blood pressure should be taken into account.

During the period of treatment, it is recommended to periodically conduct a peripheral blood test, including when sore throat occurs when swallowing or fever. This will make it possible to diagnose agranulocytosis in a timely manner and establish cases of the development of severe leukopenia.

The absence of anticholinergic action in Trittico allows its appointment for prostate hypertrophy, angle-closure glaucoma, impaired cognitive functions, and elderly patients.

If, while taking the pills, the patient develops a prolonged and inadequate erection, it is necessary to consult a doctor.

Drinking alcohol is contraindicated while taking Trittico.

Influence on the ability to drive vehicles and complex mechanisms

Trittico has a weak sedative effect, which can negatively affect the patient's ability to concentrate and reduce the speed of his psychomotor reactions. In this regard, during the period of treatment, it is necessary to abandon the performance of potentially hazardous activities, including the management of vehicles and complex mechanisms.

Application during pregnancy and lactation

The use of Trittico is contraindicated during gestation and lactation.

Pediatric use

The use of Trittico is contraindicated for the treatment of children under 6 years of age.

Special care should be taken when prescribing Trittico to patients under the age of 18.

At the age of 6 to 18 years, the dose is prescribed, taking into account the patient's weight, at the rate of 1.5–2 mg per 1 kg of body weight per day and divided into several doses. If necessary, the initial dose can be gradually increased, observing an interval of 3-4 days. The maximum daily dose should not exceed 6 mg per 1 kg of body weight.

With impaired renal function

Trazodone should be used with caution in renal failure.

For violations of liver function

Trazodone should be used with caution in liver failure.

Use in the elderly

For elderly patients, the initial daily dose of Trittico is selected individually, it should not exceed 100 mg. It is taken once before bedtime or divided into two doses. Dose escalation should be carried out under medical supervision, taking into account the effectiveness and tolerability of trazodone. It is not recommended to exceed the maximum daily dose of 300 mg.

Drug interactions

With the simultaneous use of Trittico:

carbamazepine: may cause a decrease in the concentration of trazodone in the blood plasma;
ketoconazole, ritonavir, fluoxetine, indinavir (inhibitors of cytochrome P450 CYP3A4): can cause a significant increase in the content of trazodone in the blood plasma, increasing the risk of adverse events. Consideration should be given to reducing the dose of trazodone when combined with potent CYP3A4 inhibitors;
antihypertensive drugs: can enhance their effect, therefore, consideration should be given to lowering their dose;
clonidine, methyldopa and other drugs that depress the central nervous system: may increase their effect;
antihistamines and anticholinergic drugs: cause an increase in the anticholinergic effect of trazodone;
tricyclic antidepressants, loxapine, maprotiline, haloperidol, phenothiazine, thioxanthene, pimozide: there is an increase and prolongation of the period of their sedative and anticholinergic effects;
mAO inhibitors: increase the risk of developing unwanted effects of trazodone;
digoxin, phenytoin: the level of their concentration in blood plasma increases.

Analogs

Trittico analogs are: Amitriptyline, Velaksin, Venlaxor, Mirtastadin, Melitor, Mirzaten, Prefaxin.

Terms and conditions of storage

Keep out of the reach of children.

Store at temperatures up to 25 ° C.

The shelf life is 3 years.

Trittico is a drug that is recommended to be taken in the presence of alcoholic depression that develops during the long-term use of alcoholic beverages. The manifestation of a depressed state negatively affects the quality of human life. Joylessness and a hazy future makes people cling to a glass and return to a state of intoxication, in which problems and hardships remain “out there,” a state of apathy sets in.

It is especially difficult for those who are trying to fight the dangerous cravings for alcohol. Along with sobriety comes unjustified anxiety, insomnia, restlessness and excessive irritability. All these symptoms must be eliminated.

As a rule, antidepressants are used in the case of alcoholic depression, Trittico is one of the drugs of the antidepressant group. It reduces the craving for alcohol and at the same time has a sedative effect on the patient. The entire range of actions and indications contains instructions for use for Trittico.

In no case should you take medicines on your own, without visiting narcologists and psychologists! This is fraught with dangerous consequences. Get tested in specialized clinics, doctors will write out a detailed treatment plan and give recommendations.

Composition

It is produced in the form of oblong, bilaterally convex tablets, on the surface above and below the engraving of risks, 75 mg and 150 mg each. The package contains instructions for Trittico along with the preparation.
Composition in the table:

Produced by the Italian pharmaceutical company Aziende Chimike Riunite Angelini Francesco A.K.R.A.F. S.p.A.

pharmachologic effect

The drug Trittico has an antidepressant effect, which is provided by the active ingredient trazadone hydrochloride. Muscle relaxant efficacy is achieved through a calming and sedative effect on mental and somatic symptoms such as:

excessive excitability;
feeling of fear;
difficulty falling asleep;
migraine;
soreness in the muscles;
increased heart rate.

The mechanism of action is due to the similarity with some subspecies of serotonin receptors.

Trittico restores the quality of sleep, normalizes the emotional and nervous state, reduces dependence and craving for alcohol. It has a beneficial and effective effect on patients who are depressed against the background of anxiety-depressive disorder during the period of withdrawal.

When taking the drug, sexual functions are restored. With a long course, there is no addiction to the drug. It has no effect on body weight.

A high rate of drug absorption - entering the bloodstream through the intestines.

Interaction with plasma proteins - 90-95%. It is excreted from the body through the kidneys and bile.

Indications for use

The drug Trittico is prescribed for:

depressive state, including: anxiety in Alzheimer's disease, degradation of cognitive function;
benzodiazepine dependence;
alcoholism in the acute stage;
depression against the background of psychogenic disorder;
erectile dysfunctions and decreased libido against the background of depressive disorders.
lethargy and fatigue;
various unfounded fears;
frequent, persistent migraines;
attempted suicide.

Contraindications

The drug should not be used in the following cases:

the period of pregnancy and breastfeeding;
an allergic reaction to the components of the drug or their rejection by the body;
arrhythmia and tachycardia.

Pay special attention in the presence of diseases:

syndrome of impaired kidney and liver function;
hypertonic disease;
atrioventricular block (AV);
priapism;
myocardial infarction.

Attention! Those who have recently had a heart attack are advised to be especially careful when taking the medication Trittico, as it can affect cardiac functions!

Instructions for use

The correct dosage, which the doctor prescribes, will help to maximize the effectiveness of the drug effect. The prescription is issued on an individual basis, after passing the examination and based on the results of the necessary tests.

Uncontrolled treatment with Trittico can lead to a deterioration in health, self-prescription and self-medication are prohibited!

Usually, at the beginning of therapy, an increased dose of the drug is prescribed, which is reduced during treatment, this allows you to bypass the manifestation of side effects.

Special instructions for admission:

At the initial stage of treatment, the dosage should be no more than 100 mg per day. Trittico tablets are taken once. Better at night, as there is a possibility of dizziness. Later, in the course of therapy, the dosage is increased by the doctor by 50 mg.

On an outpatient basis, the daily dose of the drug should be within 450 mg, in inpatient therapy, the daily dose should not exceed 600 mg.
Patients with a weakened immune system and the elderly are not recommended to take more than 75 mg per day.
In the fight against alcoholism, complex therapy is carried out with the participation of the medication Trittico and starts with 100 mg of the drug with a gradual increase in dosage (medical supervision is required!).

Overdose

Overdose symptoms can manifest itself in:

bouts of nausea;
excessive sleepiness;
hypertension.

If symptoms occur, be sure to stop taking the medicine and flush your stomach with a mild baking soda solution.

Side effects

When taking the drug, the following side effects are possible:

CNS: asthenia, drowsiness, dizziness, insomnia, migraine, hyperactivity, myalgia, disorders of the musculoskeletal system, paresthesia, disorientation, blurred perception, tremors in the body.

Cardiovascular system: slowing or accelerating heart rhythms, conduction, bradycardia, lowering blood pressure, postural hypotension.
Gastrointestinal tract: nausea with vomiting, diarrhea, discomfort in the mouth.
Vision: impaired visual function, redness of the eyes.
Hematopoiesis: leukopenia, neutropenia.
In addition, the sinuses are laid, the possibility of priapism with the development of impotence, allergic manifestations.

Interaction

Cases have been recorded when Trittico was taken together with drugs:

Amiodarone: development of ventricular tachycardia;
Varafavine: Weakening the effectiveness of Barafavine;
Diagoxin: the possibility of increasing the concentration of digoxin in the blood plasma, which leads to symptoms of intoxication;
Carbamazepine: an increase in the plasma concentration of this substance;
Lithium salts: the likelihood of tremors, chills, reversible symptoms of neurotoxicosis;
Pseudoephedrine: the appearance of feelings of anxiety, anxiety and unreasonable fear, blurred consciousness, disorder of self-perception;
Tryptophan: anorexia, psychosis, prolonged hyperactivity occurs and progresses;
Thioridazine: the likelihood of increased plasma concentration of trazodone;
Phenytoin: development and intensification of side effects of Phenytoin;
Fluoxetine: the likelihood of more pronounced side effects of fluoxetine;
Chlorpromazine and Trifluoperazine: there is a possibility of increased blood pressure;
Ethanol: enhancement of the depressant effect on the central nervous system.

The drug is sold in pharmacies, as prescribed by a doctor.

Examine the box carefully; the release date should be stamped on it. The shelf life of the medicinal product is 3 years. Do not take expired medications!

special instructions

In some cases, the drug must be taken with caution:

liver and kidney disease;
high / low blood pressure;
heart diseases;
children under 18 years old.

To date, there are no analogues of Trittico in terms of the active substance. The mechanism of action is similar for the following drugs:

Azafen;
Befol;
Valdoxan;
Deprim;
Inkazan;
Kraxil;
Lerivon;
Mirzaten;
Amitriptyline;
Simbalta;
Velfalaxin;
Tsipralex.

The cost of Trittico's analogs is much lower than the original, but they do not have the efficiency that Trittico can achieve in a short time.

Using the medicine with alcohol

It is strongly discouraged to consume alcoholic beverages while taking Trittico. Alcohol causes an increase in blood pressure. The tablets act with the opposite effect, as a result of which there is a risk of hypoxia. Severe dizziness is a symptom of hypoxia, which can make a person faint.

In addition, the simultaneous intake of these two substances slows down the oxidation of alcohol and leads to acute intoxication of the body and the destruction of liver cells.

The effect of the drug will be mild due to alcohol relief. Practically no result other than harm, treatment will bring.

Remember, even a drop of alcohol will return you to the starting position and you will have to start the treatment again!

During pregnancy (and lactation)

Persons suffering from liver dysfunctions of a different nature should be taken with caution.

Reviews about Trittico

Like all drugs of a medical nature, this remedy is not suitable for everyone. According to patients' reviews about Trittico, after a course of therapy with this drug, their sleep quality improved, the feeling of anxiety and nervousness disappeared, and the emotional state returned to normal. Importantly, their cravings for vodka, beer and wine have weakened, their potency has recovered.

The doctors' comments about Trittico are based on long-term observation of the dynamics of patient treatment and are positive. According to doctors, the effect of taking the pills makes itself felt pretty quickly. Alcohol depression goes away along with the attraction to intoxicating drinks and neuroses.

To master the general information, be sure to read reviews about Trittico on medical sites and forums.

The medical product Trittico is registered in the register of medicines of the Russian Federation (RLS) under the code number P N015703 / 01, 2009-07-15.

The price of Trittico averages 648 rubles for 20 tablets of 150 mg each. (Approximate cost, check prices in pharmacies at the place of residence).

bezokov.com

Detailed description and effectiveness of the drug Trittico

Trittico medicine, even with prolonged use, is not addictive. It does not promote weight gain and is neutral to the uptake of dopamine and norepinephrine.

Indications and contraindications, side effects

disorders of potency and libido, including those caused by depressive conditions;
benzodiazepine dependence;
depressive conditions accompanied by high anxiety against the background of diseases of the central nervous system (Alzheimer's disease, dementia, cerebral atherosclerosis);
alcoholism;
psychogenic depression;
violation of the emotional state due to prolonged pain syndrome;
alcoholic depression.

Do not use Trittico in the following cases:

lactation period;
pregnancy;
high sensitivity to the main and / or additional components of the drug.

It is necessary to take this product with special care by persons who drive a vehicle, since a loss of concentration is not excluded.

Trittico is not prescribed for children under 6 years of age. It is prescribed with caution when:

atrioventricular block;
episodes of priapism in history;
ventricular arrhythmias;
myocardial infarction;
postinfarction period;
arterial hypertension;
liver failure;
heart problems;
renal failure.

It should be borne in mind that the drug Trittico has side effects that may occur while taking it. They manifest themselves as follows:

drowsiness;
bitterness in the mouth;
increased fatigue;
orthostatic hypotension;
hypotension;
allergic reactions in various parts of the body;
paresthesia;
headaches, asthenia;
severe dry mouth;
arrhythmia;
dizziness;
increased arousal;
anorexia;
violations of myocardial conduction;
pain;
disorientation;
myalgia;
neutropenia;
nausea;
diarrhea;
tremor;
eye irritation;
bradycardia;
priapism;
leukopenia;
lowering blood pressure;
lack of coordination;
vomiting.

The dosage of the drug is prescribed depending on the patient's condition and his illness. Moreover, it must be selected by the attending physician after a thorough examination of the patient. Blood test results are important. Indeed, if a person has a deficiency of leukocytes, then taking this drug in a large dosage can aggravate the situation, since it helps to reduce their number.

Alcohol and medicine Trittico

alko03.ru

Description of the drug

Pharmacists note that even with prolonged use of this pharmacological drug, it is not addictive.

Trittico tablets are completely neutral to the capture of norepinephrine and dopamine. Therefore, those taking the medication do not have to worry about weight gain.

It has an active thymoleptic and anxiolytic effect on the patient's body.
Increases the depth and duration of patients' sleep during treatment
Reduces the pathological craving for ethanol decreases with proper intake.
Eliminates anxiety and depression.

Indications and contraindications

The drug Trittico is indicated for use in the following cases:

Depressive conditions, which are accompanied by increased anxiety against the background of Alzheimer's disease, dementia or atherosclerosis of the cerebral vessels.
Disruption of the normal emotional state due to prolonged pain syndrome.
Alcoholism (acute alcoholic syndrome) and psychogenic depression.
Libido and potency disorders that could be triggered by depressive disorders.
Increased fatigue and slowed down thinking.
Bulimia, phobias.
Constant acute migraine attacks.
Suicidal attempts.

Contraindications include:

Pregnancy and lactation period.
Hypersensitivity or complete intolerance to the components of the product.
Arrhythmia and tachycardia.

Trittico tablets should be taken with extreme caution for the following diseases:

Renal and hepatic impairment.
Arterial hypertension.
Atrioventricular block.
A history of priapism.
Myocardial infarction.

Care should be taken when taking these tablets after a recent heart attack, as they can adversely affect the work of the heart.

But still, the medicine has its own side effects:

Most of the above side effects are due to excessive use of Trittico, that is, an overdose.

Instructions for use

Much depends on the blood tests. If a person has a white blood cell deficiency, a large dosage can only worsen his health, as the drug will further reduce the number of white blood cells.

Features of taking the drug:

The initial dose for adult patients should not exceed 150 mg per day twice a day.
It is advisable to use the tablets at bedtime, as they may cause severe dizziness.
If necessary, the doctor will recommend increasing the daily dose by another 50 mg. The maximum daily dose for outpatients should not exceed 450 mg, and for inpatients - 600 mg.
Elderly and immunocompromised patients should not take more than 75 mg per day.
In mild forms of depression, you can take a prophylactic agent of no more than 150 mg in three days with two-day breaks.

The effectiveness of the drug

In 50% of patients, the positive effect of Trittico tablets is manifested within 2-3 days after regular intake of the drug. But 25% see the effect of using the drug only after two weeks.

In some patients, progress occurs only after four weeks of taking Trittico. In this case, everything is very individual.

The danger of the simultaneous use of alcohol and Trittico pills lies in the destructive effect that is on the patient's liver. The drug is excreted from the body through this internal organ.

As a result, the patient will have to undergo treatment again. In this case, it is recommended to take the medicine during remission. But the dosage should be reduced after consulting your doctor.

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Signs of pathology

Depression is characterized by decreased self-esteem, apathy, and a deep indifference to one's life and the world around us. Quite often, a depressed person finds addiction to alcohol and drugs. However, this method does not solve the problem and does not remove the cause of the depressive state, but only relieves the symptoms. In addition, the use of alcohol and drugs aggravates a person's mental state, making them lost.

Depression as a mental disorder is more common among women; men rarely become victims of this disease. People between the ages of 18 and 55 are at greatest risk of becoming depressed, but in rare cases, the disorder may develop earlier or later.

Kinds

The disease is divided into certain types depending on the reasons for its occurrence:

Treating depressive disorders is necessary, as the lack of help can lead to consequences in the future. This will not only seriously affect human health in general, but can also develop into more serious mental pathologies. The pharmaceutical market offers a wide range of drugs aimed at treating and relieving symptoms of depression. Among them, doctors often prescribe Trittico, an antidepressant trazodone, a triazolopyridine derivative. The drug creates an antidepressant effect, simultaneously exerting an anxiolytic and sedative effect on the body. Reviews about Trittico abound.

Mechanism of action

Unlike tricyclic antidepressants and MAO inhibitors, trazodone does not affect monoamine oxidase. The action of trazodone is due to the high degree of affinity of the drug for certain types of serotonin receptors. Trazodone interacts with them agonistically or antagonistically, and also has the ability to cause blocking of serotonin reuptake. This is confirmed by the instruction attached to the Trittico preparation.

It has a quick effect on the symptoms of anxiety, mental and somatic, such as irritability, insomnia, fear, affective tension, headaches, palpitations, increased urination, hyperventilation, sweating and muscle pain.

"Trittico" effectively relieves sleep disorders, increasing its duration and depth, as well as positively affecting its quality and physiological structure. In addition, in chronic alcoholics during the period of abstinence, the drug is able to normalize the emotional background, raise the mood, and reduce the craving for alcohol. The drug is effective in the treatment of depressive disorders in patients who are addicted to benzodiazepine derivatives. During remission, trazodone should completely replace benzodiazepines. Another effect of the drug is to increase potency and libido. Moreover, for this purpose, the drug can be used by patients who do not suffer from depressive disorders.

According to reviews, there is no addiction to Trittico. It does not affect dopamine and norepinephrine uptake or weight gain.

Composition

One tablet contains 150 mg of trazodone hydrochloride and excipients (sucrose, lovidone, carnauba wax and magnesium sterate).

The drug has a high degree of absorption from the gastrointestinal tract. It is impossible to use the drug together with food or immediately after, as this slows down the absorption. In the liver, the active substance is metabolized. 75 percent of metabolites are excreted by the kidneys. Complete elimination of the drug from the body occurs 98 hours after administration.

Indications

The indications for the appointment of Trittico tablets are:

Anxiety-depressive disorders of the endogenous type. This also includes involutional depressions.
Neurotic and reactive psychogenic depression.
Depressive disorders as a consequence of pathologies of the central nervous system: atherosclerosis, Alzheimer's disease, dementia, etc.
Depression against the background of prolonged pain syndrome.
Alcoholic depressive disorders.
Violations of potency and libido, including against the background of depression.
Benzodiazepine dependence.

Side effects

According to reviews, the following conditions can become side effects from taking the drug "Trittico":

Drowsiness.
Fast fatiguability.
Headaches.
Nervous excitement.
Dizziness.
Myalgia.
Weakness.
Discoordination.
Disorientation.
Tremor.
Paresthesias.
Decrease in blood pressure.
Arrhythmia.
Orthostatic hypotension as a consequence of the adrenolytic effect of taking the drug.
Bradycardia.
Neutropenia and leukopenia.
Violation of conductivity.
Feeling of bitterness in the mouth and dryness.
Diarrhea.
Nausea and vomiting.
Allergic reactions.
Decreased appetite.
Eye irritation.
Priapism.

The appearance of these symptoms is a reason to stop taking the drug and consult your doctor.

Contraindications

According to the instructions, "Trittico" is contraindicated in the following cases:

Pregnancy and lactation.
Children under the age of 6.
Individual intolerance to the components of the drug.

Prescribing the drug to children under the age of 18 should be done with the utmost care. For elderly and debilitated patients, it is necessary to select an individual dosage regimen. Starting from the minimum dose, it can be increased, depending on how the patient's body reacts to therapy. Usually, a sufficient daily dose of Trittico tablets is 300 mg.

Instructions for use

Trittico is available in 75 and 150 mg tablets.

The drug is taken orally half an hour before meals or at least two hours after. The tablet cannot be chewed; it must be swallowed whole and washed down with plenty of clean water.

Adult patients at the beginning of treatment are prescribed 100 mg one time just before going to bed. Starting from the fourth day of therapy, an increase in dosage up to 150 mg is allowed. To achieve the maximum effect of therapy with Trittico, the daily dosage should be increased by 50 mg every 4 days until it reaches 300 mg. Starting from 150 mg, the dose should be halved. Most of it is taken before bedtime, and less in the afternoon. For outpatients, an increase in the maximum daily dosage is provided to 450 mg, for inpatients it can be 600 mg.
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For the treatment of decreased libido, the daily dosage is 50 mg. In the case of monotherapy in the treatment of impotence, it is recommended to take 200 mg per day, with combined therapy - 50 mg.

Therapy for benzodiazepine dependence presupposes a specific treatment regimen based on a gradual decrease in the dose of benzodiazepine and its replacement with the antidepressant Trittico. Reducing the benzodiazepine dosage by ½ tablet, add 50 mg of trazodone. Further three weeks nothing changes, then the reduction of benzodiazepine continues until it is completely canceled. Once this point is reached, a gradual withdrawal of 50 mg trazodone every three weeks begins.

The initial daily dosage for the elderly is 100 mg. It can be taken once at bedtime or divided into two doses. Dosage increases should only take place under medical supervision. Most often, there is no need for a daily dosage of more than 300 mg.

Children aged 6 to 18 years are prescribed up to 2 mg per kilogram of body weight per day. Reception is divided into several times a day. The dosage may be increased to 6 mg per kilogram per day.

Interaction with other drugs

"Trittico" reduces the effect of certain antihypertensive drugs, which may require a reduction in their dosage.

The effects of drugs such as methyldol and clonidine, which can depress the central nervous system, are also enhanced when taken with trazodone.

Antihistamine drugs with anticholinergic activity increase the effectiveness of trazodone.

Trittico and alcohol are incompatible. This leads to hypoxia and a deterioration in general well-being. "\u003e

The drug prolongs and enhances the anticholinergic and sedative effect of taking tricyclic antidepressants, loxapine, haloperidol, phenothiazine, thioxanthene, limoside and maprotiline.

Concomitant use of trazodone with MAO inhibitors significantly increases the risk of adverse reactions. This combination, among other things, increases the accumulation of phenytoin and digoxin in the blood plasma.

It also interacts with substances such as ritonavir, indinavir, ketoconazole, and fluoxetine. These components increase the concentration of trazodone in the blood. The analogs of the drug "Trittico" should be selected by a doctor.

special instructions

Since the drug is able to exhibit a certain adrenolytic activity, against the background of its administration, bradycardia may appear, as well as a decrease in blood pressure. For this reason, its appointment to patients with problems of the cardiovascular system should be carried out with an assessment of the possible risks. The same applies to patients with recent myocardial infarction, cardiac conduction disturbances and AV block of varying severity.

Taking the drug "Trittico" can cause a slight decrease in the level of leukocytes in the blood, but this phenomenon does not need special treatment, unless it reaches a level of pronounced leukopenia.

During the course of therapy with this drug, it is necessary to regularly conduct a microbiological blood test, especially if you have a sore throat or fever. The side effects of Trittico are described in detail above.

The drug has no anticholinergic effect. Therefore, it can be taken by older people who have a history of prostatic hypertrophy, cognitive impairment, or angle-closure glaucoma.

Available only by prescription. Unreasonable or too prolonged erections are the reason for seeking medical attention. The use of alcohol during the period of therapy is prohibited.

Since the drug has an anxiolytic and sedative effect, a decrease in attention and speed of psychomotor functions may occur. Therefore, for the duration of therapy, it is better to give up driving vehicles, controlling high-precision mechanisms and other hazardous activities.

Reviews about "Trittico"

Reviews allow us to understand that the drug is not a strong antidepressant. It is ineffective to use it in monotherapy. However, as part of complex therapy, it gives positive results.

Experts note the undoubted effect of taking the drug for nervous disorders and stress. It perfectly relieves irritability and anxiety, helps to distract from pain and improves the mood of patients.

Analogs of "Trittico"

The drug has no analogues for the active substance. The mechanism of action and belonging to one pharmacological group are similar to it: "Azafen", "Befol", "Deprim", "Kraxil", "Lerivon", "Negrustin" and others.

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Antidepressant Trittico

Composition and form of release

Pharmacodynamics and pharmacokinetics

Indications for use

somatogenic, psychotic, neurotic or endogenous depression;
decreased libido and sexual activity;
insomnia and other sleep disorders;
disorders of appetite and eating behavior (bulimia, anorexia);
increased fatigue, chronic fatigue syndrome;
various phobias, obsessive states;
dependence on benzodiazepine drugs.

How to take Trittico

old age - the daily dosage is gradually increased from 100 to 300 mg;
sexual desire disorder - daily dose of 50 mg;
children's age (from 6 to 18 years old) - 1.5 mg per kilogram of weight.

special instructions

During pregnancy

In childhood

Drug interactions

Trazodone actively interacts with substances of other antidepressants and potent drugs, therefore, the instructions for use describe the following features of the interaction of Trittico:

enhances the anticholinergic and sedative effect of drugs such as Haloperidol, Phenothiazine, Pimozide, Thioxanthen, Loksapin, tricyclic antidepressants;
increases the effect of drugs that lower blood pressure;
co-administration with monoamine oxidase inhibitors increases the risk of side effects and the concentration of Digoxin and Phenytoin in blood plasma;
co-administration with carbamazepine will reduce the plasma concentration of trazodone.

Trittico and alcohol

Trittico side effects

Overdose

Contraindications

arterial hypertension;
chronic tachycardia;
early recovery period after myocardial infarction;
individual intolerance to the components of the drug.

Terms of sale and storage

Analogs

Azafen;
Befol;
Valdoxan;
Deprim;
Inkazan;
Kraxil;
Lerivon;
Simbalta.

Trittico price

Video

Reviews

Maria, 36 years old

I was prescribed Trittico during the period of postpartum depression, from which I could not get out for almost two years. I did not experience any effect from taking the drug, although I took everything in accordance with the doctor's recommendations. In addition, during the period of treatment, she gained almost 7 kg. After two months of use, the therapist prescribed another remedy.

Maxim, 46 years old

I took Trittico when I was in the drug dispensary with a diagnosis of alcoholism. I did not notice any significant changes in mood, or a decrease in craving for alcohol. He took the drug as prescribed - twice a day, gradually increasing the dose. After therapy, he came out of depression with the help of other medications prescribed by another doctor.

Olga, 29 years old

During depression after losing a child, I was prescribed Trittico - I carefully studied its instructions for use and, after some doubts, drank the course. The condition improved significantly after three weeks of admission - sleep, appetite improved, mood began to rise. I drank two tablets a day. I did not notice any side effects.

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Trittico

Features:

During treatment, it is necessary to refrain from using ethanol. Elderly patients suffering from angle-closure glaucoma and enlargement of the prostate gland are allowed to be treated with the drug.

Indications:

Reception scheme:

Contraindications:

Side effects:

Treatment may be accompanied by drowsiness and headaches, weakness, fatigue and bitterness in the mouth. Active ingredient The active ingredient is trazodone hydrochloride.

Supporting components

Also included are: sucrose and carnauba wax, povidone and magnesium stearate.

What you need to know before taking the antidepressant Trittico: instructions, reviews

Trittico (Trazodone) is an antidepressant that belongs to the triazolopyridine group. It is produced in the form of long-acting biconvex tablets, white, 75 and 150 mg of the active ingredient.

The composition contains the active ingredient trazodone hydrochloride and impurity components: wax, cane sugar, magnesium stearate, povidone.

pharmachologic effect

The functional component of the drug is trazodone, which has an antidepressant effect with a sedative and anxiolytic effect.

Also, the drug is able to normalize an excited pathetic state, restores potency and improves mood.

Addiction to this drug was not recorded. The active ingredient has no anticholinergic activity and therefore has no effect on heart function.

The algorithm of functioning of Trittico lies in the ability to influence the serotonergic system. The active substance selectively blocks the return rejection of serotonin.

Pharmacokinetics of the drug

The drug has a high absorption rate from the gastrointestinal tract. Simultaneous intake of the drug with food slows down the absorption time.

Indications and contraindications for use

Trittico is prescribed for the following diseases:

Contraindications to the appointment of the drug:

hypersensitivity to the active ingredient of the drug;
period of pregnancy;
children up to age six;
hepatic or renal impairment;
a history of priapismoma;
the manifestation of symptoms of ventricular premature beats;
arterial hypertension;
the initial period of remission after a heart attack;
the presence of tachycardia.

Instructions for use

Trittico tablets are prescribed for internal use, 30 minutes before a meal, or four hours after a meal.

In general, the total daily amount of medication should not exceed 150 mg at a time. The drug use regimens differ depending on the age category of patients:

Age 18. The daily dose is calculated in the amount of 1-2 mg per body weight. The set amount is divided into several steps. If necessary, the daily amount of the drug can be gradually increased every three days to a total dose of 6 mg per 1 kg of body weight.
Elderly and malnourished patients. The course of therapy for this category of patients begins with a dose of 100 mg per day. Further, the amount of the drug is increased to a total daily dose of 300 mg.

Overdose and side effects

Of the side effects, the following reactions appear:

cardiovascular system - decrease in blood pressure, leukopenia, neutropenia, bradycardia, impaired conduction;
digestive system - diarrhea, vomiting, nausea, decreased appetite;
the main and peripheral nervous system - severe fatigue, disorientation, trembling, dizziness, numbness of the limbs and general weakness.

To get rid of all of the above symptoms, you need to carry out symptomatic therapy and remove the remnants of the medication from the body with the help of diuretic drugs.

The active ingredient trazodone can enhance the effects of certain antihypertensive medications. In this case, it is required lower doses of both medicines.

When used synchronously with drugs that suppress the central nervous system, the effect of the latter is significantly augmented.

When taken simultaneously with MAO blockers and carbamazepine, the likelihood of undesirable effects increases.